Business
Vor Bio Reports Second Quarter 2023 Financial Results and Provides Company Update
Next trem-cel clinical data update expected by year-end 2023VCAR33ALLO IND cleared by U.S. FDA; Rapidly activating sites toward study initiationSecured
About this update from Vor Biopharma Inc.
[{"type":"text","content":"Next trem-cel clinical data update expected by year-end 2023VCAR33ALLO IND cleared by U.S. FDA; Rapidly activating sites toward study initiationSecured non-exclusive license to Cas9 gene-edited HSCs CAMBRIDGE, Mass., Aug. 10, 2023 (GLOBE NEWSWIRE) -- Vor Bio (Nasdaq: VOR), a clinical-stage cell and genome engineering company, today reported financial results for the three-month period ended June 30, 2023, and provided a business update. “We are pleased with the progress we have made during the quarter. The recent clearance of our IND for VCAR33ALLO represents a significant step forward in our vision of creating a Treatment System for acute myeloid leukemia which may enable more potent and durable responses in the post-transplant setting without on-target toxicity,” said Dr. Robert Ang, Vor Bio’s President and Chief Executive Officer. “We also look forward to sharing further engraftment and Mylotarg hematologic protection data from our VBP101 clinical study by year-end.” Corporate Updates Trem-cel clinical trial (VBP101) continues to actively enroll patients; next data update expected by year-end 2023 Clinical data presented at the European Hematology Association 2023 meeting by Dr. Guenther Koehne, a clinical investigator for the VBP101 study, showed primary neutrophil engraftment in the first five patients treated and demonstrated consistent manufacturing of trem-cel with high CD33 editing efficiency.The Company plans to provide its next VBP101 clinical update by year-end 2023. The data set is expected to include engraftment data for additional patients receiving a trem-cel transplant and further Mylotarg™ hematologic protection data.Following a planned safety review of initial patients receiving trem-cel, the enrollment stagger requiring engraftment prior to transplanting subsequent patients was removed and is expected to increase the pace of enrollment. Trem-cel is a genome-edited allogeneic hematopoietic cell transplant (HCT) that is lacking the CD33 protein. It is designed to replace standard of care transplants for patients suffering from AML and potentially other blood cancers. Trem-cel has the potential to enable powerful targeted therapies in the post-transplant setting including Mylotarg and CD33-targeted CAR-Ts. VCAR33ALLO IND cleared by the U.S. Food & Drug Administration (FDA) The U.S. FDA has cleared the Company’s ...