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Volition Announces MARS Consortium Clinical Study Suggests Nu.Q® H3.1. Concentrations are Closely Associated with Sepsis and Organ Failure
VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition"), a multi-national epigenetics company, today announced the publication of a new clinical manuscript suggesting that the Nu.Q® H3.1 biomarker has the potential to inform clinical care in critically-ill Intensive Care Unit (ICU) patients in the assessment of sepsis, organ failure and subphenotypes.
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[{"type":"text","content":"Peer Reviewed Clinical Study for H3.1 Biomarker Published in Critical Care ","length":74,"tagName":"p"},{"type":"text","content":"HENDERSON, Nev., June 12, 2025 /PRNewswire/ -- VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition"), a multi-national epigenetics company, today announced the publication of a new clinical manuscript suggesting that the Nu.Q® H3.1 biomarker has the potential to inform clinical care in critically-ill Intensive Care Unit (ICU) patients in the assessment of sepsis, organ failure and subphenotypes.","length":413,"tagName":"p"},{"type":"text","content":"Dr. Andrew Retter, Chief Medical Officer, Volition said:","length":61,"tagName":"p"},{"type":"text","content":""This independent peer-reviewed and published study (1713 patients) clearly demonstrates that Nu.Q® H3.1 is a clinically meaningful, biologically specific marker of NETosis, with actionable potential in defined patient subgroups."","length":240,"tagName":"p"},{"type":"text","content":""H3.1 nucleosomes reflect the biological process 'NETosis,' supporting the emerging paradigm of "treatable traits" and biologically-informed risk stratification of patients."","length":202,"tagName":"p"},{"type":"text","content":""This evidence positions the assay not as a traditional rule-in/rule-out diagnostic, but as a dynamic tool for prognostic enrichment, therapeutic targeting, and clinical monitoring."","length":192,"tagName":"p"},{"type":"text","content":"Lieuwe D.J. Bos, PhD, ICU Research, Principle Investigator at the Amsterdam University Medical Center, Amsterdam and Senior Author of the paper added:","length":150,"tagName":"p"},{"type":"text","content":""In this large observational study, we demonstrated that plasma nucleosomes, represented by H3.1 nucleosome concentration, are associated with the presence of sepsis, the severity of organ dysfunction, and a hyperinflammatory host response."","length":251,"tagName":"p"},{"type":"text","content":""Patients with acute kidney injury (AKI), disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS) exhibit significantly higher Nu.Q® H3.1 levels compared to those without these conditions."","length":236,"tagName":"p"},{"type":"text","content":""The implications of our results are that N...