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miRagen Therapeutics Announces Positive Data for Cobomarsen in Adult T-Cell Leukemia/lymphoma Patients With Residual Disease
Cobomarsen-treated adult T-cell leukemia/lymphoma (ATLL) patients with residual disease had a median survival time (MST) of 26 months compared with 7.4 months
About this update from Viridian Therapeutics, Inc.
[{"type":"text","content":"Cobomarsen-treated adult T-cell leukemia/lymphoma (ATLL) patients with residual disease had a median survival time (MST) of 26 months compared with 7.4 months in a historical cohort- - -\n Median progression free survival (PFS) of 12.5 months compared with 5.4 months in a historical cohort- - -Generally safe and well tolerated by ATLL patients and observed to have a favorable safety profile over one year of dosing on a weekly schedule BOULDER, Colo., Jan. 30, 2020 (GLOBE NEWSWIRE) -- miRagen Therapeutics, Inc. (NASDAQ: MGEN), a clinical-stage biopharmaceutical company developing proprietary RNA-targeted therapies with a specific focus on microRNAs, today announced new efficacy and safety data from the ATLL arm of its ongoing Phase 1 clinical trial of cobomarsen, which will be presented at the 12th Annual T-Cell Lymphoma Forum in La Jolla, CA, which is taking place from January 30th to February 1st. Of note are the data from the subtype of aggressive ATLL patients who at study entry had persistent residual disease after chemotherapy or other therapy. In the trial, six patients of this subtype had an MST of 26 months with three patients still on treatment at the time of data analysis (October 17, 2019). The Company was most encouraged, however, by the observed biomarker activity showing that disease stabilization is marked by a decrease in biomarkers of tumor cells activation and proliferation, providing evidence of the biological mechanism effect of cobomarsen on disease stabilization. “New data from the ATLL arm of our Phase 1 clinical trial offer insights into the potential efficacy and safety of cobomarsen in treating patients with this deadly cancer. We believe that the survival, biomarker and safety data generated by this study is particularly notable as patients with aggressive ATLL historically have a poor prognosis,” said miRagen President and CEO William S. Marshall, Ph.D. “We believe these data support the continued development of cobomarsen in ATLL, particularly as a maintenance therapy in those patients with residual disease after front line therapy. This observed anticancer activity in patients with ATLL combined with our previously reported results in cutaneous t-cell lymphoma, further strengthen our view that cobomarsen may be effective in the potential treatment of a variety of cancers where miR-155 is elevated. D...