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Veru Announces the Presentation of Updated Data from the Phase 1b/2 Sabizabulin Study in Men with Metastatic Castration Resistant Prostate Cancer at the 2022 ASCO Genitourinary Cancers Symposium
MIAMI, Feb. 17, 2022 (GLOBE NEWSWIRE) -- Veru Inc. (NASDAQ: VERU), an oncology biopharmaceutical company with a focus on developing novel medicines for the
About this update from Veru Inc.
[{"type":"text","content":"MIAMI, Feb. 17, 2022 (GLOBE NEWSWIRE) -- Veru Inc. (NASDAQ: VERU), an oncology biopharmaceutical company with a focus on developing novel medicines for the management of breast and prostate cancer, today announced that updated clinical data from the positive Phase 1b/2 study of sabizabulin in 80 men with metastatic castration resistant prostate cancer who have progressed on at least one novel androgen receptor targeting agent will be presented at the 2022 ASCO Genitourinary Cancers Symposium being held February 17-19, 2022 in San Francisco, CA. Sabizabulin is an oral new chemical entity that represents a novel class of agents that target unique binding sites on microtubules to disrupt the cytoskeleton. Highlights of the Presentation:In this updated analysis of all 80 patients in the Phase 1b/2 clinical study, sabizabulin treatment demonstrated both cytotoxic and cytostatic antitumor activity. Evidence of antitumor activity was observed with PSA reductions and objective and durable tumor responses. For patients with measurable disease at baseline (n=29), the overall response rate was 20.7%. The best clinical response (stable disease or objective tumor response) in patients with measurable disease at study entry was 59% (17/29). At the time of data cut off for this presentation, 5 of the responders remain on study with the longest approaching 3 years on sabizabulin. Chronic daily dosing with sabizabulin was feasible and well tolerated with no clinically relevant neutropenia or neurotoxicity. This Phase1b/2 clinical study supports the efficacy and safety assumptions for the ongoing Phase 3 VERACITY clinical study evaluating sabizabulin in metastatic castration and androgen receptor targeting agent resistant prostate cancer prior to IV chemotherapy. Presentation details:Presentation Date/Time: February 17, 2022Abstract Title: Sabizabulin has both cytotoxic and cytostatic activity in Phase 1b/2 clinical trials of men with metastatic castration-resistant prostate cancer who progressed on androgen receptor-targeting agents.Presenter: Mark C. Markowski MD, PhD, Assistant Professor, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins UniversityAbstract Number: 110 Additional information on the meeting can be found on the ASCO Genitourinary Cancers Symposium website: https://conferences.asco.org/gu/attend “There have been significant...