Press release
Verastem Oncology to Present Mature RAMP 201 Data in Low-Grade Serous Ovarian Cancer at the International Gynecologic Cancer Society 2024 Annual Meeting
Late-breaking abstract of the mature RAMP 201 data evaluating avutometinib plus defactinib in low-grade serous ovarian cancer to be featured as oral plenary
About this update from Verastem, Inc.
[{"type":"text","content":"\nLate-breaking abstract of the mature RAMP 201 data evaluating avutometinib plus defactinib in low-grade serous ovarian cancer to be featured as oral plenary presentation\n\n BOSTON--(BUSINESS WIRE)--\nVerastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with cancer, today announced the acceptance of a late-breaking abstract of the mature data from the ongoing Phase 2 RAMP 201 (ENGOT-ov60/GOG-3052) clinical trial to be presented as an oral presentation at a plenary session at the International Gynecologic Cancer Society (IGCS) Annual Meeting taking place October 16-18, 2024 in Dublin, Ireland. The presentation will include updated safety and efficacy data from the RAMP 201 trial evaluating the combination of avutometinib, a RAF/MEK clamp, and defactinib, a selective FAK inhibitor, in patients with low-grade serous ovarian cancer (LGSOC), including overall response rate, progression free survival, and duration of response.\n\n“The robust interim data from the ongoing RAMP 201 clinical trial in LGSOC, announced earlier this year, enabled us to initiate the rolling NDA submission to the FDA,” said Dan Paterson, president and chief executive officer of Verastem Oncology. “We look forward to the oral presentation at IGCS of the mature RAMP 201 data and engaging with experts in ovarian cancer as part of the international gynecologic community. We also remain on track to finalize our clinical module and complete our NDA submission in the fourth quarter of this year.”\n\nAbout the Avutometinib and Defactinib Combination\n\nAvutometinib is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. In contrast to currently available MEK-only inhibitors, avutometinib blocks both MEK kinase activity and the ability of RAF to phosphorylate MEK. This unique mechanism allows avutometinib to block MEK signaling without the compensatory activation of MEK that appears to limit the efficacy of other MEK-only inhibitors.\n\nVerastem Oncology is currently conducting clinical trials with avutometinib in RAS/MAPK driven tumors as part of its Raf And Mek Program or RAMP. RAMP 301 (NCT06072781) is an international Phase 3 confirmatory trial evaluating the combin...