Press release
Verastem Oncology Outlines Key 2022 Strategic Priorities and Upcoming Catalysts for Advancing VS-6766 as a Backbone of Therapy for RAS Pathway-Driven Cancers
Report Selection Phase (Part A) Results from RAMP 201 and RAMP 202 Evaluating VS-6766 Alone and in Combination with Defactinib in Low-Grade Serous Ovarian
About this update from Verastem, Inc.
[{"type":"text","content":"\nReport Selection Phase (Part A) Results from RAMP 201 and RAMP 202 Evaluating VS-6766 Alone and in Combination with Defactinib in Low-Grade Serous Ovarian Cancer (LGSOC) and KRAS-Mutant Non-Small Cell Lung Cancer (NSCLC), Respectively\n\nReport Preliminary Data from Phase 1/2 Trial Evaluating LUMAKRAS™ (sotorasib) and VS-6766 and Initiate Phase 1/2 Trial Evaluating adagrasib and VS-6766; Both in KRAS G12C-Mutant Non-Small Cell Lung Cancer\n\nExpand Ongoing Investigator-Initiated Trial Program to Explore Combination Potential with VS-6766 in Additional Areas of High Unmet Need; Data Read-Outs Expected Throughout 2022\n\n BOSTON--(BUSINESS WIRE)--\nVerastem Oncology (Nasdaq:VSTM), a biopharmaceutical company committed to advancing new medicines for patients battling cancer, today outlined key strategic priorities and upcoming catalysts to support its lead compound VS-6766 in 2022. VS-6766 is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF, potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition. VS-6766 is currently in late-stage development.\n\n“Building on the Breakthrough Therapy designation for VS-6766 with defactinib in recurrent low-grade serous ovarian cancer, the significant progress of our RAMP program in both low-grade serous ovarian cancer and KRAS G12V-mutant non-small cell lung cancer, our clinical collaborations in KRAS G12C-mutant non-small cell lung cancer as well as our ongoing investigator-initiated trials program, we expect to see tremendous progress on behalf of patients in 2022,” said Brian Stuglik, CEO of Verastem Oncology. “We plan to efficiently advance our development strategy, report multiple data readouts and further highlight the differentiated potential of VS-6766 across tumor types and mutations.”\n\n2022 Strategic Priorities\n\nGynecologic Oncology Program\n\n\nFully enroll Part B of the RAMP 201 trial (LGSOC VS-6766 +/- defactinib).\n\n\nExpand development program into other RAS pathway-driven gynecologic cancers.\n\n\nNon-Small Cell Lung Cancer (NSCLC) Program\n\n\nSelect regimen for Part B of the RAMP 202 trial (KRAS G12V NSCLC VS-6766 +/- defactinib).\n\n\nInitiate and complete dose-finding portions of RAMP 203 (KRAS G12C NSCLC VS-6766 + LUMAKRASTM (sotorasib)) and RAMP 204 (KRAS G12C NSCLC VS-6766 + adagrasib) ...