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New Data To Be Shared at 2023 ASCO Demonstrate Power of Veracyte’s Decipher GRID To Help Advance Molecular Understanding of Prostate Cancer
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)-- Veracyte, Inc. (Nasdaq: VCYT) announced that new data to be shared at the 2023 American Society of Clinical
About this update from Veracyte, Inc.
[{"type":"text","content":" SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--\nVeracyte, Inc. (Nasdaq: VCYT) announced that new data to be shared at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting demonstrate the ability of the company’s Decipher Genomics Resource for Intelligent Discovery (GRID) database to enable novel molecular insights into prostate cancer. The findings, from three separate studies, may ultimately help inform more personalized treatment for patients with prostate cancer.\n\n\n“The Decipher GRID-based data that will be shared at this year’s ASCO meeting help advance our collective understanding of how to use transcriptomic information in the treatment of prostate cancer,” said Elai Davicioni, Ph.D., Veracyte’s medical director for Urology. “This includes new insights into specific molecular profiles that may predict individual tumors’ response to treatment. The findings also shed light on transcriptomic differences underlying various types of prostate cancer and the changes that occur over the course of the disease as well as in response to therapy.”\n\n\nA poster presentation on June 3 (Abstract #5094; Poster #188) will highlight findings from an analysis of the Phase 3 randomized clinical trial NRG/RTOG 0521, which examined the role of molecular subtyping in prediction of response to docetaxel chemotherapy among patients with high-risk prostate cancer who were treated with radiation and androgen deprivation therapy (ADT). Researchers classified 183 pre-treatment biopsy samples into basal or luminal subtypes using a Decipher GRID-derived, 215-gene expression signature. This signature was previously shown to classify prostate cancer into four molecular subtypes: luminal differentiated, luminal proliferating, basal immune, and basal neuroendocrine-like. Patients in this trial were followed for a median of 9.9 years.\n\n\nResults suggest that patients with high-risk localized prostate cancer that is classified as a luminal proliferating (LP) subtype derive greater benefit from the addition of docetaxel to RT and ADT than those with non-LP subtypes. Differences in restricted mean survival times (RMST), a measure of the average survival time gained or lost by receiving chemotherapy, were examined at 5 and 10 years. Among patients who received docetaxel, at 5 years, LP subtype patients on average gained 3.8 months in overa...