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New Real-World Durability of Response Data for JELMYTO Reports 68% Recurrence-Free Survival Rate (RFS) at Three Years Across a Broad Patient Population with Low-Grade Upper Tract Urothelial Cancer (LG-UTUC)
-No RFS difference based on use of JELMYTO for primary chemoablation versus post-endoscopic ablation as adjuvant therapy -No RFS difference based on tumor
About this update from Urogen Pharma Ltd.
[{"type":"text","content":"\n-No RFS difference based on use of JELMYTO for primary chemoablation versus post-endoscopic ablation as adjuvant therapy\n\n\n-No RFS difference based on tumor size, location, number of tumors or route of administration\n\n\n-Maintenance treatment in a small group linked to higher RFS\n\n\n PRINCETON, N.J.,--(BUSINESS WIRE)--\nUroGen Pharma Ltd. (Nasdaq: URGN), a biotech company dedicated to developing and commercializing innovative solutions that treat urothelial and specialty cancers, today highlights results from a study on the durability of response from the first and largest post-commercialization study of JELMYTO® (mitomycin) for pyelocalyceal solution. The long-term study evaluated 56 patients who achieved complete response after treatment with JELMYTO from 15 high-volume academic and community centers and helps characterize how urologists are now using JELMYTO in their practices. This long-term study titled, “Durability of Response of UGN-101: Longitudinal Follow-Up of Multicenter Study,” is published online in Urologic Oncology: Seminars and Investigations.\n\n\n\"The three-year durability data from this study further validate the potential of JELMYTO in providing long-term disease control for patients with low-grade upper tract urothelial cancer,” said Solomon L. Woldu, MD, Assistant Professor of Urology, UT Southwestern Medical Center, Dallas, Texas, and study investigator. “Notably, we found that recurrence-free survival was not influenced by factors like tumor size or location, highlighting the broad applicability of this treatment. The potential benefits of maintenance therapy are encouraging, and further research will be key in confirming its role in improving outcomes for these patients.”\n\n\nIn this study on durability of response, 68% of patients with LG-UTUC who initially responded to JELMYTO had no evidence of disease recurrence at 3 years, as evaluated via endoscopy. The median follow-up was 23.5 months. RFS did not vary significantly based on use of JELMYTO for chemoablative versus adjuvant intent, tumor location (pyelocalyceal versus ureteral), tumor size before induction, single versus multiple tumors, or JELMYTO administration route (antegrade versus retrograde). The administration of maintenance treatment did appear to be associated with significantly better RFS, however, only 15 patients received ma...