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Unicycive Therapeutics Announces Publication of Positive Comparison of Oxylanthanum Carbonate to Commercially Available Phosphate Binders in the American Journal of Nephrology
Newly Assigned USAN Name, Oxylanthanum Carbonate, replaces Lanthanum Dioxycarbonate LOS ALTOS, Calif., July 18, 2023 (GLOBE NEWSWIRE) -- Unicycive
About this update from Unicycive Therapeutics, Inc.
[{"type":"text","content":"Newly Assigned USAN Name, Oxylanthanum Carbonate, replaces Lanthanum Dioxycarbonate\nLOS ALTOS, Calif., July 18, 2023 (GLOBE NEWSWIRE) -- Unicycive Therapeutics, Inc. (Nasdaq: UNCY), a clinical-stage biotechnology company developing therapies for patients with kidney disease (the “Company or “Unicycive”), today announced that the peer-reviewed international journal the American Journal of Nephrology has published positive results on the phosphate binding capacity for oxylanthanum carbonate (OLC). The Company also announced the adoption of the non-proprietary name, oxylanthanum carbonate (OLC) by the United States Adopted Name (USAN) organization, replacing lanthanum dioxycarbonate (LDC) which has been used in previous publications and company presentations. OLC is Unicycive’s investigational phosphate binding agent utilizing proprietary nanoparticle technology being developed as a lower pill burden option for the treatment of hyperphosphatemia in chronic kidney disease (CKD) patients on dialysis. The publication, entitled, “High Phosphate-Binding Capacity of Oxylanthanum Carbonate with a Low Medication Volume: Comparison with Commercially Available Phosphate Binders,” showed that OLC had the lowest daily phosphate binder dose volume and the lowest volume required to bind 1 g of phosphate compared to five other commercially available phosphate binders. “The published data supports our other studies demonstrating that oxylanthanum carbonate has the potential to improve medication adherence and the quality of life for patients suffering from CKD,” said Shalabh Gupta, MD, CEO of Unicycive. “A key focus for management of CKD is phosphate control, but currently available binders have suboptimal phosphate-binding capacity, and their characteristics often result in low adherence and suboptimal phosphate regulation. OLC has the potential to reduce the pill burden compared to commercially available products—a key point of differentiation in the phosphate binder market.” For patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), regulation of phosphate levels between 3.0 and 4.5 mg/dl is crucial to preserve the proper function of many biological processes, including energy metabolism, skeletal development, and bone integrity. The development of hyperphosphatemia, a condition where serum phosphorus concentration ris...