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Mereo BioPharma and Ultragenyx Present Data from the Phase 2b ASTEROID Study of UX143 (setrusumab) in Osteogenesis Imperfecta (OI) at the American Society for Bone and Mineral Research (ASBMR) 2021 Annual Meeting
Previously reported data demonstrated dose-dependent, statistically significant bone-building effect at multiple anatomical sites in adult patients with OI
About this update from Ultragenyx Pharmaceutical Inc.
[{"type":"text","content":"Previously reported data demonstrated dose-dependent, statistically significant bone-building effect at multiple anatomical sites in adult patients with OI that was consistent across subtypes of OI Dose-dependent improvements in serum biomarkers of bone turnover with UX143 therapy confirm sclerostin inhibition mechanism of action LONDON and NOVATO, Calif., Oct. 01, 2021 (GLOBE NEWSWIRE) -- Ultragenyx Pharmaceutical Inc. (Nasdaq: RARE), a biopharmaceutical company focused on the development and commercialization of novel products for serious rare and ultra-rare diseases, and Mereo BioPharma Group plc (Nasdaq: MREO), a clinical stage biopharmaceutical company focused on oncology and rare diseases, today presented secondary endpoint data on UX143 (setrusumab) from the Phase 2b ASTEROID study for the Treatment of Osteogenesis Imperfecta (OI). Data were presented at the American Society for Bone and Mineral Research (ASBMR) 2021 Annual Meeting in an oral presentation by Suzanne Jan de Beur, M.D., an associate professor of medicine at The Johns Hopkins University School of Medicine and president of ASBMR. Previously reported analyses of pre-specified endpoints in the Phase 2b ASTEROID study demonstrated a clear, dose-dependent, statistically significant bone-building effect at multiple anatomical sites in adult patients with OI that was consistent across all subtypes of OI studied, including Types I, III and IV. This effect was determined by evaluating areal bone mineral density (BMD) over baseline at the lumbar spine, as measured by DXA and reaching 8.97% at 12 months in the highest dose cohort (p","length":2127,"tagName":"div"}]