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TScan Therapeutics Announces Publication in Cell Highlighting the Discovery of Tumor Antigens and TCRs for the Treatment of Solid Tumors Using Foundational Screening Technology
TScan screening technology used to identify the targets of expanded T cell clones in the tumors of patients with head and neck cancer responding to
About this update from Tscan Therapeutics, Inc.
[{"type":"text","content":"TScan screening technology used to identify the targets of expanded T cell clones in the tumors of patients with head and neck cancer responding to neoadjuvant immunotherapy TCR for C*07:02-restricted epitope on MAGE-A1 forms the basis of TScan’s TSC-204-C07 TCR-T therapeutic candidate for the treatment of solid tumors Paper published in collaboration with lead authors Kai W. Wucherpfennig, M.D., Ph.D., Director, Center for Cancer Immunology Research, Dana-Farber Cancer Institute and Jonathan D. Schoenfeld, Associate Professor, Radiation Oncology, Harvard Medical School WALTHAM, Mass., July 11, 2022 (GLOBE NEWSWIRE) -- TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biopharmaceutical company focused on the development of T cell receptor (TCR) engineered T cell therapies (TCR-T) for the treatment of patients with cancer, today announced the publication of a peer-reviewed article titled, “Tissue-resident Memory and Circulating T cells are Early Responders to Pre-surgical Cancer Immunotherapy” in the journal Cell. The data highlight the ability of TScan’s unbiased, genome-wide screening technology to identify novel target antigens and highly active TCRs for adoptive T cell cancer therapies, including the TCR that has now become the Company’s therapeutic candidate TSC-204-C07 for MAGE-A1. This publication details the characterization of tumor-infiltrating and circulating T cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a Phase 2 open-label randomized clinical trial conducted by the Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School1. Single cell analysis revealed that tumor-infiltrating CD8 T cells that expanded upon treatment with checkpoint blockade exhibited specific and identifiable gene expression signatures. Analysis of the TCRs of these expanded T cells using TScan’s screening technology revealed several novel targets. In one responding patient, two different T cell clones recognized the same novel C*07:02-restricted epitope on the cancer/testis antigen MAGE-A1, and both TCRs exhibited strong anti-cancer activity. One of these TCRs forms the basis of TScan’s therapeutic candidate TSC-204-C07 for MAGE-A1, with an IND filing planned for the second half of 2022. “We are very pleased that our screening technology successfully identified the targ...