Business
TScan Therapeutics Announces 2023 Clinical Plans and Highlights Recent Progress
Phase 1 umbrella trial of TSC-100 and TSC-101 active in five sites; on track to enroll first two cohorts in 1H 2023 with interim data by end of 2023 Advancing
About this update from Tscan Therapeutics, Inc.
[{"type":"text","content":"Phase 1 umbrella trial of TSC-100 and TSC-101 active in five sites; on track to enroll first two cohorts in 1H 2023 with interim data by end of 2023 Advancing solid tumor program with development of several TCRs for multiple HLAs across multiple targets; INDs filed for two MAGE-A1 TCRs (TSC-204-A0201 and TSC-204-C0702) as well as IND for multiplexing TCRs Cash runway funds operations into 2Q 2024 WALTHAM, Mass., Jan. 05, 2023 (GLOBE NEWSWIRE) -- TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biopharmaceutical company focused on the development of T cell receptor (TCR)-engineered T cell therapies (TCR-T) for the treatment of patients with cancer, today announced its 2023 clinical pipeline plans and highlighted recent corporate achievements. “We made significant progress and growth in 2022, positioning both our solid tumor and hematologic malignancies programs for important data readouts in 2023,” said David P. Southwell, President and Chief Executive Officer. “Our solid cash runway funds us well into 2024, seeing us through to multiple value-generating milestones. We believe that 2023 will be a pivotal year for TScan as we continue to advance our industry-leading clinical stage portfolio of TCR-T therapy candidates in both our solid tumor and hematologic malignancies programs.” Debora Barton, M.D., Chief Medical Officer added, “We look forward to multiple clinical milestones next year. Specifically, we expect an interim data read out from our Phase 1 umbrella trial in prevention of relapse post-transplant for hematological malignancies as well as preliminary data for our most advanced solid tumor TCRs by the end of 2023.” 2022 Key Achievements and Recent Company Highlights Hematologic Malignancies Program: FDA clearance of IND applications for TSC-100 and TSC-101 for the prevention of relapse following hematopoietic cell transplant (HCT) in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and acute lymphocytic leukemia (ALL)Initiated multi-arm clinical trial with five clinical sites activated, with additional sites to be added in 2023Presented Phase 1 umbrella trial in progress poster on HA-1 (TSC-100) and HA-2 (TSC-101) at the 64th American Society of Hematology (ASH) annual meeting 2022 Phase 1 trial design and translational assays designed to show early evidence of biological activity in residual leuke...