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Tonix Pharmaceuticals Extends Research Collaboration with the University of Alberta to Develop Antiviral Drugs Against SARS-CoV-2
Tonix Exercises Option to License Antiviral Technology Platform NEW YORK, May 18, 2022 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP)
About this update from Tonix Pharmaceuticals Holding Corp.
[{"type":"text","content":"Tonix Exercises Option to License Antiviral Technology Platform\nNEW YORK, May 18, 2022 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced it has entered into a license agreement and extended a research collaboration with the University of Alberta, a leading Canadian research university, focused on identifying and testing broad-spectrum antiviral drugs against future variants of SARS-CoV-2 and other emerging viruses. “We are excited to extend our collaboration with Tom Hobman, Ph.D., Professor, Department of Cell Biology, University of Alberta, and to have exercised an option to license the technology,” said Seth Lederman, M.D., President and Chief Executive Officer. “Antiviral therapeutics are needed to mitigate the effects of SARS-CoV-2 and future coronavirus outbreaks, and Professor Hobman’s work is designed to facilitate the identification and testing of novel broad-spectrum antiviral drugs. SARS-CoV-2 is very sensitive to interferon (IFN) treatment and therefore, drugs that upregulate IFN production and/or signaling may reduce virus replication.” “The research collaboration is focused on the development and testing of Wnt/β-Catenin signaling pathway inhibitors as broad-spectrum antivirals against SARS-CoV-2 and other emerging viruses,” said Professor Tom Hobman. “During the first phase of the sponsored research, we showed that small molecules that inhibit this pathway also decrease replication of SARS-CoV-2 genomic RNA and dramatically reduce infectious viral titers. Drugs in this class seem to work by inducing peroxisome biogenesis, which in turn enhance production of Type I and III IFNs when cells detect viral genetic material. Peroxisomes are key antiviral signaling platforms that are important for IFN induction and antiviral defense. We believe this work has the potential to lead to drugs that limit the spread and disease burden of SARS-CoV-2 and other RNA viruses, which will support the goal of pandemic preparedness.” About Tonix Pharmaceuticals Holding Corp.1 Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing therapeutics to treat and prevent human disease and alleviate suffering. Tonix’s portfolio is composed of central nervous system (CNS), rare disease,...