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Tonix Pharmaceuticals Announces Research Agreement with the French National Institute of Health and Medical Research (Inserm) to Study the Mechanism of Oxytocin-Mediated Improvement of Eating Behaviors in Prader-Willi Mice
Tonix is Developing TNX-2900 (Intranasal Potentiated Oxytocin) for the Treatment of Prader-Willi in Adolescents and Adults with Hyperphagia or Excessive
About this update from Tonix Pharmaceuticals Holding Corp.
[{"type":"text","content":"Tonix is Developing TNX-2900 (Intranasal Potentiated Oxytocin) for the Treatment of Prader-Willi in Adolescents and Adults with Hyperphagia or Excessive Eating Planned Studies in Prader-Willi Mice Will Focus on Oxytocin-Mediated Normalization of Suckling in Newborns CHATHAM, N.J., Feb. 28, 2022 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced that it has entered into a sponsored research agreement with Inserm Transfert, the private subsidiary of Inserm, on behalf of Inserm (the French National Institute of Health and Medical Research) and Aix-Marseille Université to study oxytocin in the genetically engineered mouse model of Prader-Willi syndrome, a rare genetic disorder that causes distinct, but related pathological eating disorders in adults and newborns. In adults, Prader-Willi causes hyperphagia, or pathological over-eating, which leads to obesity and other complications associated with significant mortality. In newborns, Prader-Willi causes a deficiency in suckling, which has been shown to be normalized by oxytocin treatment. “Tonix is excited to enter into this new research collaboration, which we hope will expand our understanding of oxytocin’s potential to treat Prader-Willi syndrome,” said Seth Lederman, M.D., Chief Executive Officer of Tonix Pharmaceuticals. “Currently, there is no approved treatment for Prader-Willi syndrome. With this new research collaboration, our goal is to learn how oxytocin-based pharmacological treatment improves and normalizes feeding behavior in infancy.” Tonix is developing TNX-2900* (intranasal potentiated oxytocin) for the treatment of Prader-Willi Syndrome in adults and adolescents. A related intranasal potentiated oxytocin product candidate, TNX-1900*, is under development for the treatment of chronic migraine and is expected to enter a Phase 2 clinical trial for the prevention of migraine headache in chronic migraineurs in the second half of 2022. The proposed research, directed by Professor Françoise Muscatelli at the Institut de Neurobiologie de la Méditerranée (INMED-Inserm UMR1249/Aix-Marseille Université), will involve in vitro and in vivo studies designed to characterize the mechanism by which oxytocin normalizes the suckling and maturation of feeding behavior during infancy i...