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Tonix Pharmaceuticals Announces Presentation of Licensed Antiviral Drug Technology at the 4th Symposium of the Canadian Society for Virology
Oral Presentation Describes Activity of Wnt/β-Catenin Signaling Pathway Inhibitors Against SARS-CoV-2 in Cell Culture and in an Animal Model CHATHAM, N.J.,
About this update from Tonix Pharmaceuticals Holding Corp.
[{"type":"text","content":"Oral Presentation Describes Activity of Wnt/β-Catenin Signaling Pathway Inhibitors Against SARS-CoV-2 in Cell Culture and in an Animal Model\nCHATHAM, N.J., June 08, 2022 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced that Tom Hobman, Ph.D., Professor, Department of Cell Biology, University of Alberta, presented data from his laboratory at The University of Alberta as a keynote presentation at the 4th Symposium of the Canadian Society for Virology held in Edmonton, Alberta, Canada on June 5, 2022. The oral presentation titled, “The virus-host Interface: A treasure trove of novel antiviral targets,” includes research sponsored by Tonix Pharmaceuticals focused on the development and testing of Wnt/β-Catenin signaling pathway inhibitors as broad-spectrum antivirals against SARS-CoV-2 and other emerging viruses. Tonix has previously announced that it exercised an option to license the antiviral technology platform A copy of the presentation is available on the Tonix Pharmaceuticals corporate website at www.tonixpharma.com. “We are excited by the progress of Professor Hobman and his colleagues at The University of Alberta on the further testing of Wnt/β-Catenin signaling pathway inhibitors as broad-spectrum antivirals,” said Seth Lederman, M.D., President and Chief Executive Officer of Tonix. “Professor Hobman presented data showing that three different Wnt/β-Catenin inhibitor drug candidates decreased lung infection in an animal model of SARS-CoV-2 infection. The set of Wnt/β-Catenin inhibitors tested by Professor Hobman include drugs that have been previously studied in humans for other indications including one drug that is FDA approved. Professor Hobman believes that reducing β-Catenin levels with Wnt-inhibitor drugs induces peroxisome proliferation and enhances the interferon response. Previously, SARS-CoV-2 was shown to be sensitive to inhibition by interferon2. Professor Hobman reported that Wnt/β-Catenin inhibitor and peroxisome inducing drugs also inhibit Zika virus (ZIKV) and Mayaro (MAYV) virus in cell culture. Tonix is excited to have sponsored Professor Hobman’s research involving Wnt/β-Catenin signaling pathway inhibitors as broad-spectrum antivirals and to have licensed the technology. We look forward to working ...