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Todos Medical Announces Publication in Nature Neuroscience That Describes the Main Protease (3CL Protease) Causes Microvascular Brain Pathology
Todos Medical Announces Publication in Nature Neuroscience That Describes the Main Protease (3CL Protease) Causes Microvascular Brain Pathology.
About this update from Todos Medical Ltd.
[{"type":"text","content":"\n New York, NY, and Tel Aviv, ISRAEL, Oct. 25, 2021 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical, Ltd. (“Todos Medical”) (OTCQB: TOMDF), a comprehensive medical diagnostics and related solutions company, today announced the publication of an article entitled “The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells” in the peer-reviewed scientific journal Nature Neuroscience (https://www.nature.com/articles/s41593-021-00926-1) by researchers at the University of Lübeck in Germany.  The article describes the mechanisms through which the main protease (Mpro, Nsp5, 3CL protease, 3CLpro or 3CLpro) cleaves the nuclear factor (NF)-κB essential modulator (NEMO) which is involved in signaling cascades that regulate the transcription of numerous genes, including the antiviral type I interferons and other immune genes. The publication concludes that “Mpro-mediated damage of the brain endothelial cells suggests that inhibitors of Mpro may prevent neurological complications of the SARS-CoV-2 infection.” Todos Medical, together with its joint venture partner NLC Pharma, is developing Tollovir®, an Mpro (3CL protease) inhibitor currently in a Phase 2 clinical trial for treatment of hospitalized COVID-19 patients with interim data expected from the trial in the fourth quarter of 2021. “We have long known the importance of Mpro in facilitating the replications and spread of COVID-19,” said Dr. Dorit Arad, Chief Scientific Officer of NLC Pharma. “What we are now beginning to understand is how Mpro not only facilitates viral replication, but also how it impacts the body’s ability to respond to the virus. Based on this publication, and additional work we’ve been doing to further elucidate the mechanisms through which Mpro facilitates the spread of SARS-CoV-2 and magnifies the damage the virus can cause in the body, we believe inhibitors of Mpro are ideal drug targets. This gives us great confidence in Tollovir’s potential in treating COVID-19 at all stages of disease, from prevention through hospitalization. We are currently focused on hospitalization, where the fewest treatment options exist, however we are continuing to evaluate outpatient trial designs to further expand the pot...