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Tiziana Life Sciences Announces Presentation at Alzheimer’s Association International Conference® 2022 (AAIC®) Evaluating Intranasal anti-CD3 for the Potential Treatment of Alzheimer’s Disease
Study conducted in animal models of Alzheimer’s disease finds restored microglia homeostasis and improvement in cognition NEW YORK, Aug. 01, 2022 (GLOBE
About this update from Tiziana Life Sciences Ltd
[{"type":"text","content":"Study conducted in animal models of Alzheimer’s disease finds restored microglia homeostasis and improvement in cognition\nNEW YORK, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Tiziana Life Sciences Ltd.(Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel drug delivery approaches, today announced the presentation of a study entitled, “Treatment of Alzheimer’s disease by modulation of microglial neuroinflammation by nasal anti-CD3 mAb.” In this study animal models of Alzheimer’s disease (AD) demonstrated that microglia activity was restored and cognition was improved following the dosing of intranasal anti-CD3 monoclonal antibody. The study was presented virtually at the Alzheimer’s Assoiation International Conference® (AAIC®) by Howard L. Weiner, M.D., Co-Director of the Ann Romney Center for Neurologic Diseaes at the Brigham and Women’s Hospital (BWH) and Chairman of Tiziana's Scientific Advisory Board on Sunday, July 31, 2022. Based on these results, Tiziana is evaluating conducting trials of nasal anti-CD3 (Foralumab) in patients with Alzheimer’s disease. Matthew Davis, M.D., RPh, Chief Scientific Officer and Chief Medical Officer of Tiziana Life Sciences, stated, “Dr. Weiner has identified another potentially valuable application of anti-CD3 based on its ability to stimulate the immune system to promote homeostatic microglial cells while decreasing degenerative microglial cells in the brain. This approach has been validated in patients with secondary progressive multiple sclerosis using Foralumab a fully human anti-CD3 monoclonal antibody. Foralumab has also been given successfully to patients with COVID. Dr. Weiner has conducted extensive work using anti-CD3 in neurological conditions and we look forward to beginning a program in AD at the appropriate time.” Dr. Howard Weiner, M.D., stated, “Nasal anti-CD3 provides a unique approach for treating progressive neurologic diseases by modulating microglial cells. The nasal route of immunotherapy has minimal toxicity and induces regulatory T cells locally, that then migrate to the brain to dampen brain inflammation. It is an exciting option that could open an entirely new approach for the immunotherapy of neurologic diseases. We look forward to evaluating Foralumab clinically in the area of Alzheimer’s disease.” C...