Business
University of Rochester Collaboration
University of Rochester Collaboration.
About this update from Theracryf Plc
[{"type":"text","content":"\n \nRNS Number : 8375C Evgen Pharma PLC 13 February 2020 \n\nEvgen Pharma plc \n(\"Evgen\" or \"the Company\" or \"the Group\")\n \nUniversity of Rochester Collaboration\n \nEvgen Pharma (Evgen) and The University of Rochester School of Medicine and Dentistry have entered into a Memorandum of Understanding to advance SFX-01 towards a clinical trial in chronic kidney disease (CKD).\n \nEvgen Pharma plc (AIM: EVG), the clinical stage drug development company developing sulforaphane based medicines for the treatment of multiple diseases, announces that it has entered into a Memorandum of Understanding with The University of Rochester School of Medicine and Dentistry to advance SFX-01 towards a clinical trial in chronic kidney disease (CKD).\n \nEvgen has agreed to supply SFX-01 to support a potential future clinical trial led by Dr. Thu Le, Professor of Medicine and Chief of the Division of Nephrology at the University of Rochester Medical Center.\n \nWith the assistance of Evgen, Professor Le will lead the process to secure appropriate grant funding and obtain clinical trial regulatory approval. The intention is to investigate in a randomised controlled trial whether treatment with SFX-01 can decrease kidney disease progression rate and decrease markers of oxidative stress and inflammation in CKD patients. In particular, the study will test whether patients with the null allele of the GSTM1 gene respond better than wild type or placebo-treated patients. The GSTM 1 gene is part of the GST (glutathione-S-transferase) family regulated by Nrf2, which SFX-01 is known to activate.\n \nClinical data arising from a successful trial would provide a sound rationale to apply for funding for a large randomised trial to test the efficacy of SFX-01 in slowing the rate of decline of patients with later stage CKD. Furthermore, a positive result would reinforce and establish further mechanistic evidence for future research on the effects of regulation of the Nrf2-GSTM1 pathway on kidney function.\n \nIn the United States the prevalence of CKD in adults is estimated to be circa 14%, with 140 deaths per 1,000 patients. More patients with CKD die of cardiovascular consequences than reach end-stage kidney disease (ESKD). The mainstay of therapy for CKD are angiotensin-converting enzyme inhibitors or ang...