Business
Nuvec® research update
Nuvec® research update.
About this update from Thalia Therapeutics Plc
[{"type":"text","content":"\n \nRNS Number : 6848I N4 Pharma PLC 28 November 2018 \n\n28 November 2018\n \nN4 Pharma Plc\n(\"N4 Pharma\" or the \"Company\")\nNuvec® research update and timings for further work\nN4 Pharma Plc (AIM: N4P), the specialist pharmaceutical company developing a novel delivery system for vaccines and cancer treatments, today announces a further update on the latest key research findings for the Company's Nuvec® delivery system.\n \nAs announced on 29 October 2018, research undertaken to that date indicated that the Company's Nuvec® particles themselves have demonstrated a clear adjuvant effect to help deliver a level of immune response for both messenger RNA (\"mRNA\") and plasmid DNA (\"pDNA\") encoded with the standard test antigen Ovalbumin (\"OVA\"). \n \nThe Company has now undertaken further analysis of its pDNA OVA findings and demonstrated that the immune response observed was sufficient to have produced strong levels of antibodies specific for OVA. A strong level of antibody production is essential for a vaccine to deliver immunity. The levels of antibodies produced were greater than those of in vivo-jetPEI®, an industry standard used to deliver pDNA-OVA in pre clinical studies. Furthermore, assessing the detailed classes of antibodies produced has shown that Nuvec® delivers a strong robust level of the specific antibodies needed for effective oncology and virology vaccines. \n \nThe Company has also now manufactured one new large batch of particles for its EUNCL and Adelaide research work and will be shipping particles from this batch to the relevant parties shortly. The research for these programs will now commence fully in January 2019. EUNCL is expected to deliver results towards the end of Q3 2019. The first part of the Adelaide work will take 4 weeks and start in the new year, with results expected during Q1 2019.\n \nNigel Theobald, CEO of N4 Pharma commented:\n\"These results are once again another positive step forward for our Nuvec® delivery platform. The data now shows Nuvec® is capable of producing specific and relevant strong levels of antibodies required for the development of vaccines and cancer treatments.\n\"We will continue to provide updates as we add to our already encouraging data package to aid our commercial collaboaration discussions. The production ...