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TG Therapeutics Announces Phase I Data Presentation for TG-1701, a Once-Daily BTK Inhibitor, as a Single Agent and in Triple Combination with Ublituximab and Umbralisib (U2), at the 61st American Society of Hematology Annual Meeting and Exposition
Proprietary triplet of U2 plus TG-1701 (BTK inhibitor) induced 86% ORR (6 of 7) in patients with relapsed/refractory NHL and CLL at the lowest dose of TG-1701
About this update from Tg Therapeutics, Inc.
[{"type":"text","content":"Proprietary triplet of U2 plus TG-1701 (BTK inhibitor) induced 86% ORR (6 of 7) in patients with relapsed/refractory NHL and CLL at the lowest dose of TG-1701 tested\n Single agent TG-1701 induced responses at multiple dose levels (including the lowest dose tested) across multiple B-cell diseases TG-1701 demonstrates an encouraging safety profile to date, with dose escalation continuing for the combination with U2 Yesterday, TG announced positive early data from the combination of U2 plus venetoclax in an oral presentation at ASH (click here for PR) Investor and analyst event to be held today, Monday, December 9, 2019 at 7:30 PM ET at the Hyatt Regency Orlando, featuring a fireside chat with leading clinical investigators NEW YORK, Dec. 09, 2019 (GLOBE NEWSWIRE) -- TG Therapeutics, Inc. (NASDAQ: TGTX), today announced the first clinical data from the Company’s once daily, oral, BTK inhibitor, TG-1701, as a single agent and as a triple therapy in combination with ublituximab (TG-1101), the Company’s novel glycoengineered anti-CD20 monoclonal antibody, and umbralisib (TGR-1202), the Company’s oral, dual inhibitor of PI3K delta and CK1 epsilon, in patients with relapsed/refractory non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Data from this Phase I trial are being presented this evening during a poster session at the 61st American Society of Hematology (ASH) Annual Meeting and Exposition. Michael S. Weiss, Executive Chairman and Chief Executive Officer, stated, “We are highly encouraged by the first clinical data presented from our once daily, BTK inhibitor, TG-1701, which has demonstrated superior selectivity for BTK compared to ibrutinib in an in vitro whole kinome screening. The data presented today show that TG-1701 is an active BTK inhibitor as a single agent and that the combination of U2 plus TG-1701 has been generally well tolerated and active with 6 of 7 patients responding to the triple therapy at 100 mg QD, the lowest dose of TG-1701 tested. We look forward to continuing dose escalation of TG-1701 in the combination arm and identifying the optimal dose for this therapy.” Mr. Weiss continued, “Our goal has always been to develop the best possible combination treatment options for patients, and we are excited to present the first data from a triple combination study in which all of the agents are bei...