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New Data for BRIUMVI® Demonstrate 89.9% of Patients with Relapsing Multiple Sclerosis Were Free from Disability Progression After 6 Years of Continuous BRIUMVI Treatment
During year 6 of continuous treatment with BRIUMVI the annualized relapse rate was 0.012, equivalent to one relapse occurring every 83 years of patient
About this update from Tg Therapeutics, Inc.
[{"type":"text","content":"During year 6 of continuous treatment with BRIUMVI the annualized relapse rate was 0.012, equivalent to one relapse occurring every 83 years of patient treatment Overall safety profile of BRIUMVI remained consistent over 6 years of continuous treatment, with no new safety signals emerging with prolonged treatment NEW YORK, Sept. 24, 2025 (GLOBE NEWSWIRE) -- TG Therapeutics, Inc. (NASDAQ: TGTX), today announced updated data presentations including new six-year data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI® (ublituximab-xiiy) in patients with relapsing forms of multiple sclerosis (RMS), at the 2025 European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) annual meeting, where we and our Ex-U.S. partner, Neuraxpharm, are exhibiting. Links to each presentation as well as highlights from the presentations are outlined below. Bruce Cree, MD, PhD, MAS, Zimmermann Endowed Professor in Multiple Sclerosis, and Professor of Neurology at UCSF Weill Institute for Neurosciences, University of California, San Francisco stated, “The data for BRUIMVI at six years of continuous therapy provides compelling evidence of durable efficacy, with sustained protection against not only relapses but also disability progression. These data also underscore the benefit of early treatment with ublituximab compared to delayed treatment on disability outcomes. Furthermore, the consistency of outcomes in clinical trials compared with emerging data from observational studies is striking and strongly supports use of ublituximab in clinical practice.” Michael S. Weiss, the Company’s Chairman and Chief Executive Officer stated, “We are extremely pleased to share six years of continuous BRIUMVI treatment data demonstrating that nearly 90% of patients on BRIUMVI remained free from disability progression, coupled with one of the lowest relapse rates ever reported in a Phase 3 RMS study. These results, together with the encouraging data from our ongoing ENHANCE dosing trial and the ENABLE real-world observational study, reinforce our confidence in BRIUMVI’s potential to deliver both meaningful efficacy and real-world convenience for people with RMS.” TG PRESENTATIONS:Oral Presentation: Long-term Efficacy and Safety of Ublituximab in Relapsing Multiple Sclerosis: Results from Six Years of ULTIMATE I and II Open-label Extension Patien...