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Tetra Bio-Pharma Maps Out Cannabinoid Metabolites in Humans Following Inhalation of QIXLEEF
Tetra Bio-Pharma Maps Out Cannabinoid Metabolites in Humans Following Inhalation of QIXLEEF.
About this update from Tetra Bio-pharma Inc.
[{"type":"text","content":"\n Bioanalytical methods developed and validated for its clinical trials. Tetra initiates study to quantify phytocannabinoid metabolites and precursors and minor phytocannabinoids in human plasma. OTTAWA, April 02, 2020 (GLOBE NEWSWIRE) -- Tetra Bio-Pharma Inc. (“Tetra” or the “Company”) (TSX-V:TBP) (OTCQB:TBPMF), a leader in cannabinoid-derived drug discovery and development, is pleased to announce the launch of a study to determine the levels of cannabinoid metabolites (e.g., 7-COOH-CBD), cannabinoid precursors (e.g., CBGA) and minor cannabinoids (e.g., CBN) in the plasma of humans. This study is important to the US Food and Drug Administration (“FDA”) and Health Canada to define the levels of these compounds in patients consuming cannabis and Tetra’s inhaled drugs QIXLEEF and CAUMZ. Tetra has launched a study to quantify the levels of cannabinoid metabolites and precursors as well as minor cannabinoids in the plasma samples of humans that received QIXLEEF™ in its clinical trials. The bioanalysis of these human plasma samples will allow Tetra to better understand how THC and CBD are degraded in humans and how long these compounds remain in the blood as well as the differences between the two inhalation routes (smoking vs vaping) of consuming QIXLEEF™. Since early 2017, Tetra used validated methods to quantify the levels of CBD, THC and 11-OH-THC in the plasma of all human subjects that received QIXLEEF and PPP005. Over the last months, bioanalytical methods were developed and validated to quantify the amount of cannabinoid precursors, such as THCA, CBDA and CBGA, minor cannabinoids, including Cannabinol, Cannabichromene, Cannabigerol, and the metabolites 11-OH-THC and 11-nor-9-carboxy-THC in human samples. The methods are developed in collaboration with one of Tetra’s partners and in compliance with the FDA and OECD Principles of Good Laboratory Practices. Drug development research performed by a pharmaceutical company revealed that the oral administration of CBD can induce liver injury in patients. This discovery has led the FDA to recommend to pharmaceutical companies to study the 7-COOH-CBD metabolite. In 2019, Tetra had already launched studies to develop and validate bioanalytical methods to measure cannabinoid precursors in human plasma. Subsequent to this ...