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Tenaya Therapeutics Presents Encouraging New Clinical and Preclinical Data from HDAC6 Inhibitor Program TN-301 for the Potential Treatment of Heart Failure with Preserved Ejection Fraction at the 2023 HFSA Annual Scientific Meeting
TN-301 Demonstrates Tolerability, Potential for Once Daily Dosing, Target Engagement and Selectivity for HDAC6 in Phase 1 Clinical Trial of Healthy
About this update from Tenaya Therapeutics, Inc.
[{"type":"text","content":"TN-301 Demonstrates Tolerability, Potential for Once Daily Dosing, Target Engagement and Selectivity for HDAC6 in Phase 1 Clinical Trial of Healthy Participants Combination of Tenaya’s HDAC6 inhibitors with Empagliflozin Shows Additive Benefits in Preclinical HFpEF Model and Highlights Differentiated Mechanism of Action SOUTH SAN FRANCISCO, Calif. and CLEVELAND, Oct. 09, 2023 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today released new data for TN-301 at the 2023 Heart Failure Society of America (HFSA) Annual Scientific Meeting. TN-301 is Tenaya’s highly selective small molecule inhibitor of histone deacetylase 6 (HDAC6) being developed for the potential treatment of heart failure with preserved ejection fraction (HFpEF). \"TN-301 continues to generate promising early data as a differentiated candidate for the treatment of HFpEF, a form of heart failure with few treatment options and unacceptably low survival rates. The first-in-human data from our Phase 1 study of TN-301 demonstrated safety and tolerability in healthy participants with dose-proportional pharmacokinetics and robust target engagement,” said Whit Tingley, M.D., Tenaya’s Chief Medical Officer. “The attractive therapeutic profile seen in our Phase 1 trial of healthy participants and the additive benefits observed preclinically of HDAC6 inhibition in combination with empagliflozin support the potential for TN-301 to be utilized as a single agent or in combination with an emerging standard of care. Taken together, these data support continued development of TN-301 as a potential treatment to address the many HFpEF patients underserved by today’s treatment options.” Phase 1 Results Demonstrate Safety, Target Engagement and Suitability for Once-Daily DosingResults from the Phase 1 clinical trial of TN-301 were presented in an ePoster, Phase 1 Clinical Trial Of TN-301, A Highly Selective HDAC6 Inhibitor with Potential in HFpEF, Shows Target Engagement (#417). Tenaya initiated the randomized, double-blind, placebo-controlled Phase 1 clinical trial in September 2022 to assess the safety and tolerability of escalating, oral doses of TN-301, as well as pharmacokinetics (PK) and pharmacod...