Telomir Pharmaceuticals Confirms Telomir-1 Restores Vision and Retinal Structure in Age-Related Macular Degeneration (AMD) Animal Model Using FDA-Recognized Surrogate Endpoints

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[{"type":"text","content":"A unique oral drug candidate that is shown to restore vision and regenerate the retina in an animal model, addressing a major unmet need in ocular therapeutics","length":159,"tagName":"p"},{"type":"text","content":"MIAMI, FLORIDA / ACCESS Newswire / May 29, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir" or the "Company"), an emerging leader in age-reversal science, today announced compelling preclinical results from a study evaluating its novel oral therapeutic, Telomir-1, in a genetically modified zebrafish model of age-related macular degeneration (AMD). Following a 14-day oral dosing regimen, Telomir-1 reversed central vision response and vision acuity, restored retinal degeneration and architecture, and significantly reduced oxidative stress-achieving improvements across several FDA-recognized surrogate endpoints relevant to AMD.","length":665,"tagName":"p"},{"type":"text","content":"The study utilized the Sen57wrn-/-ND6-/+ zebrafish model, which combines genetic mutations associated with premature aging (WRN), mitochondrial dysfunction (ND6), and chronic senescence (Sen57). These animals exhibit progressive retinal degeneration, visual impairment, and oxidative stress-closely modeling dry AMD and geographic atrophy in humans.","length":349,"tagName":"p"},{"type":"text","content":"Model Transformation: From Degeneration to Recovery","length":51,"tagName":"p"},{"type":"text","content":"Before treatment, the aged (18-month-old) zebrafish demonstrated clear signs of neurodegeneration and visual impairment. Mutant animals showed sluggish, uncoordinated swimming behavior and delayed responses to visual stimuli such as light and movement-evidence of significant vision loss.","length":288,"tagName":"p"},{"type":"text","content":"Microscopic analysis of their retinas revealed approximately 15% total retinal degeneration, affecting several critical layers:","length":127,"tagName":"p"},{"type":"list","items":[{"val":[{"type":"text","content":"The inner nuclear layer (INL) was thinned. This layer acts as the retina's central processing zone, where signals from light-sensitive photoreceptors are refined before being passed deeper into the eye.","length":206,"tagName":"p"}]},{"val":[{"type":"text","content":"The ganglion cell layer (GCL) was degraded. This layer contains neurons that form the optic ...

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