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Taysha Gene Therapies Announces Poster Presentation on TSHA-102 in Rett Syndrome at Upcoming British Paediatric Neurology Association 2024 Annual Conference
DALLAS, Jan. 22, 2024 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and
About this update from Taysha Gene Therapies, Inc.
[{"type":"text","content":"DALLAS, Jan. 22, 2024 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS), today announced that it will present clinical data on its TSHA-102 program in evaluation for Rett syndrome during an oral poster presentation at the upcoming British Paediatric Neurology Association (BPNA) 2024 Annual Conference, taking place in Bristol, England from January 24-26, 2024. The presentation will include previously disclosed clinical data from the first two adult patients with stage four Rett syndrome dosed with TSHA-102 in the REVEAL Phase 1/2 adolescent and adult trial in Canada. The Company expects to provide further updates on available clinical data from cohort one (low dose) in the REVEAL adolescent and adult trial in the first quarter of 2024. Oral poster presentation details are as follows: Abstract Title: Early safety and efficacy observations following the first use of TSHA-102 gene therapy in patients with Rett Syndrome Presenter: Meredith Schultz, M.D., M.S., Senior Vice President of Clinical Development and Medical Affairs at Taysha Gene Therapies Oral Presentation Session Date/Time: Thursday, January 25 at 12:05-12:40 PM GMT Location: Screen C - Wallace Suite Poster Number: 056 Additional details on the meeting can be found at the BPNA 2024 Annual Congress website. About TSHA-102TSHA-102 is a self-complementary intrathecally delivered AAV9 investigational gene transfer therapy in clinical evaluation for Rett syndrome. TSHA-102 utilizes a novel miRNA-Responsive Auto-Regulatory Element (miRARE) technology designed to mediate levels of MECP2 in the CNS on a cell-by-cell basis without risk of overexpression. TSHA-102 has received Fast Track designation and Orphan Drug and Rare Pediatric Disease designations from the FDA and has been granted Orphan Drug designation from the European Commission. About Rett SyndromeRett syndrome is a rare neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene, which is a gene that’s essential for neuronal and synaptic function in the brain. The disorder is characterized by intellectual disabilities, loss of communication, seizures, slowing and/or regression of development, motor and respirator...