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Taysha Gene Therapies Announces Oral Presentation on TSHA-102 in Rett Syndrome at Upcoming 9th World Rett Syndrome Congress
DALLAS, Sept. 26, 2024 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA) (Taysha or the Company), a clinical-stage biotechnology company focused
About this update from Taysha Gene Therapies, Inc.
[{"type":"text","content":"DALLAS, Sept. 26, 2024 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA) (Taysha or the Company), a clinical-stage biotechnology company focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system (CNS), today announced that it will present previously disclosed clinical data on its TSHA-102 program in evaluation for Rett syndrome during an oral presentation at the upcoming 9th World Rett Syndrome Congress, taking place in Queensland, Australia from October 2-5, 2024. The presentation will entail previously disclosed positive clinical data up to 52 weeks from the ongoing REVEAL Phase 1/2 adolescent and adult trial and initial clinical data up to 22 weeks from the REVEAL Phase 1/2 pediatric trial evaluating TSHA-102 in Rett syndrome. The Company expects to provide clinical data from cohort two (high dose, n=3) and a longer-term update on clinical data from cohort one (low dose, n=2) from both the adolescent and adult, and the pediatric REVEAL trials in the first half of 2025. Oral presentation details are as follows: Abstract Title: First cohort data from the REVEAL adolescent/adult and pediatric studies of TSHA-102 gene therapy for Rett syndrome Presenter: Sukumar Nagendran, M.D., President and Head of Research and Development at Taysha Gene Therapies Session: Preclinical and Clinical Stream Date & Time: Friday, October 4, 2024, from 12:40-1:00 PM Australian Eastern Standard Time (AEST) Additional details on the meeting can be found at the 9th World Rett Syndrome Congress website. About TSHA-102TSHA-102 is a self-complementary intrathecally delivered AAV9 investigational gene transfer therapy in clinical evaluation for Rett syndrome. Designed as a one-time treatment, TSHA-102 aims to address the genetic root cause of the disease by delivering a functional form of MECP2 to cells in the CNS. TSHA-102 utilizes a novel miRNA-Responsive Auto-Regulatory Element (miRARE) technology designed to mediate levels of MECP2 in the CNS on a cell-by-cell basis without risk of overexpression. TSHA-102 has received Regenerative Medicine Advanced Therapy, Fast Track and Orphan Drug and Rare Pediatric Disease designations from the FDA, Orphan Drug designation from the European Commission and Innovative Licensing and Access Pathway designation from the Medicines and H...