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Sutro Biopharma Announces Presentation of STRO-002 Data from the Compassionate Use Program in Pediatric Patients with Relapsed/Refractory CBF/GLIS AML at ASH 2022
- A total of 17 pediatric patients were treated with STRO-002 on a compassionate use basis; eight patients achieved complete remission, of which seven
About this update from Sutro Biopharma, Inc.
[{"type":"text","content":"- A total of 17 pediatric patients were treated with STRO-002 on a compassionate use basis; eight patients achieved complete remission, of which seven patients were MRD negative - - Safety and efficacy profile in this patient population provides added confidence to advance clinical development of STRO-002, which is currently being studied in patients with advanced ovarian and endometrial cancers - - FDA recently granted Orphan Drug Designation to STRO-002 in this patient population - SOUTH SAN FRANCISCO, Calif., Dec. 10, 2022 (GLOBE NEWSWIRE) -- Sutro Biopharma, Inc. (Sutro or the Company) (NASDAQ: STRO), a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs), today announced that its research collaborators at Fred Hutchinson Cancer Research Center presented data from the Compassionate Use Program on anti-leukemic activity of STRO-002, a novel folate receptor-α (FR-α) targeting ADC, in pediatric patients with relapsed/refractory CBFA2T3-GLIS2 (CBF/GLIS) acute myeloid leukemia (AML), commonly known as RAM phenotype AML, in an oral presentation at the 64th American Society of Hematology Annual Meeting and Exposition (ASH 2022) in New Orleans, LA. STRO-002 was provided to 17 pediatric patients with CBF/GLIS subtype AML on a compassionate use basis. Clinical results from these patients were compiled by Sutro and presented as an oral presentation by Soheil Meshinchi, M.D., Ph.D., Professor, Clinical Research Division, at Fred Hutchinson Cancer Research Center; Professor, Division of Pediatric Hematology-Oncology, at the University of Washington School of Medicine; and Principal Investigator for the program, titled, “Anti-Leukemic Activity of STRO-002 a Novel Folate Receptor-α (FR-α)-Targeting ADC in Relapsed/Refractory CBFA2T3-GLIS2 AML.” “I am heartened to observe such encouraging results in children with this rare disease who have a dismal prognosis with conventional therapies and no treatment options,” commented Dr. Meshinchi. “The clinical responses to STRO-002 in this group of patients who have relapsed or are refractory to standard of care treatments, suggest that this drug is particularly promising and provides hope for patients and families impacted by this devastating disease.” CBF/GLIS subtype AML is a rare, serious and life-threatening disease affecting pediatric patient...