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Stoke Therapeutics to Present Data from the Company’s Dravet Syndrome Clinical Program at the American Epilepsy Society 2023 Annual Meeting
– New data include 24-month results from the largest and longest prospective natural history study of children and adolescents with Dravet syndrome, which
About this update from Stoke Therapeutics, Inc.
[{"type":"text","content":"\n– New data include 24-month results from the largest and longest prospective natural history study of children and adolescents with Dravet syndrome, which showed a lack of improvement despite treatment with available medicines –\n\n\n– Additional presentations include data that support advancement of STK-001 as potentially the first disease-modifying new medicine for Dravet syndrome, including data showing substantial reductions in seizures and improvements in cognition and behavior as well as pharmacokinetic modeling –\n\n\n BEDFORD, Mass.--(BUSINESS WIRE)--\nStoke Therapeutics, Inc. (Nasdaq: STOK), a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines, today announced that presentations related to the Company’s work in Dravet syndrome will be presented at the American Epilepsy Society (AES) 2023 Annual Meeting, taking place December 1 – 5, in Orlando, Florida. The company is advancing STK-001 as potentially the first medicine to address the genetic cause of Dravet syndrome.\n\n\n“People living with Dravet syndrome typically experience high rates of seizures and debilitating effects on neurodevelopment, including behavioral and developmental delays, movement and balance issues, and delayed language and speech, among other life-altering challenges, which current treatments do not adequately address,” said Barry Ticho, M.D., Ph.D., Chief Medical Officer of Stoke Therapeutics. “We look forward to sharing the findings from more than 3 years of clinical studies, including important new data from the longest and largest prospective natural history study of patients with Dravet syndrome, which showed that despite treatment with multiple anti-seizure medicines, most patients continued to experience convulsive seizures over 24 months and that gaps in neurodevelopment persist between children with Dravet syndrome and their neurotypical peers. These data, together with the initial clinical findings from our Phase 1/2a and open label extension studies, as well as pharmacokinetic data to inform dosing, are giving us a very good understanding of how STK-001 works and highlight the critical need for a disease-modifying new medicine for Dravet syndrome.”\n\n\nDetails for the Company’s poster presentations at AES are as follows:\n\n\n\nTitle: 24-Mont...