Business
Soligenix Announces HyBryte™ Clinical Summary Published in "Expert Opinion on Investigational Drugs"
PRINCETON, N.J., March 19, 2026 /PRNewswire/ -- Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on
About this update from Soligenix, Inc.
[{"type":"text","content":"PRINCETON, N.J., March 19, 2026 /PRNewswire/ -- Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today that a summary of all the clinical trials completed to date evaluating HyBryte™ (synthetic hypericin) as a treatment for cutaneous T-cell lymphoma (CTCL) has been published in the peer-reviewed medical journal Expert Opinion on Investigational Drugs. The publication \"Topical Hypericin: A Promising Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma\" is authored by Brian Poligone, MD, PhD, the founder and Medical Director of the Rochester Skin Lymphoma Medical Group and the Director of Cancer Biology Research for the Rochester General Hospital Research Institute who has extensive clinical experience evaluating HyBryte™ with his team's participation in four HyBryte™ clinical studies. \n \n \n \n \n \n \n \nExpert Opinion on Investigational Drugs is an international monthly peer-reviewed journal, evaluating drugs in preclinical and clinical development. Authors are encouraged to express their Expert Opinion of the status of the research under review and its impact on clinical practice, rather than simply review the available data. The audience consists of scientists, managers and decision-makers in the pharmaceutical industry, and others closely involved in research and development.\"Topical synthetic hypericin represents a paradigm shift in the skin-directed management of early-stage CTCL. Its unique mechanism, excellent safety profile, and robust clinical efficacy position it as a formidable potential new agent in the therapeutic armamentarium,\" stated Dr. Poligone, Director of the Rochester Skin Lymphoma Medical Group. \"Following the positive results from the previous Phase 2 and 3 studies I participated in, as well as the ongoing confirmatory FLASH2 Phase 3 study, I was honored to be invited by Expert Opinion on Investigational Drugs to provide a definitive analysis of the HyBryte™ clinical data landscape. HyBryte™ has been demonstrated to have a non-mutagenic mechanism of action, uses a non-carcinogenic light source and appears to have improved tolerability relative to available therapies such as mechlorethamine. The rapid response rates and t...