Business
Soligenix Announces Achievement of Two-Year Stability with Bivalent and Trivalent Thermostabilized Filovirus Vaccines when Stored at High Temperatures
Vaccines stable for at least two years when stored at 40 degrees Celsius / 104 degrees FahrenheitOnly subunit (protein) vaccine platform shown to protect
About this update from Soligenix, Inc.
[{"type":"text","content":"Vaccines stable for at least two years when stored at 40 degrees Celsius / 104 degrees FahrenheitOnly subunit (protein) vaccine platform shown to protect against potentially lethal Ebola and Marburg virusesNo cold chain storage and transport required as compared to other filovirus vaccinesPRINCETON, N.J., Sept. 25, 2023 /PRNewswire/ -- Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today two-year stability of its thermostabilized bivalent and trivalent filovirus vaccine candidates at temperatures of 40 degrees Celsius (104 degrees Fahrenheit) when formulated in a single vial, needing reconstitution only with sterile water immediately prior to use. This follows the previous successful demonstration of 100% protection of non-human primates (NHPs) against lethal Sudan ebolavirus and Marburg marburgvirus challenge with the bivalent vaccine. This important milestone is part of an ongoing collaboration with the University of Hawaiʻi at Mānoa (UHM), demonstrating the successful presentation of one or more antigen(s) within the same formulation while maintaining full potency and thermostability, including vaccines for Sudan ebolavirus (SuVax™) and Marburg marburgvirus (MarVax™). It further demonstrates the broad applicability of the heat stable vaccine platform, and its potential role in the United States (U.S.) Administration's initiative for pandemic preparedness. \n\n \n \n \n \n \n \n\n \n\"Filoviruses such as Zaire ebolavirus, Sudan ebolavirus and Marburg marburgvirus are some of the most lethal viruses known, and they are endemic in areas of the world where the power supply and distribution network can be uncertain. There are no licensed vaccines for either Sudan or Marburg viruses, while vaccines for Zaire ebolavirus are constrained by cold chain logistics. A heat stable vaccine in a single vial format would significantly enhance any public health preparedness or response to a new outbreak, at its source,\" stated Axel Lehrer, PhD, Associate Professor, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, UHM. \"Our work to date has demonstrated the feasibility of rapid and efficient manufacturing, as well as...