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Positive Clinical Results from HyBryte™ Comparative Study Evaluating HyBryte™ Against Valchlor® in the Treatment of Cutaneous T-Cell Lymphoma Published in Oncology and Therapy
HyBryte™ demonstrates more rapid and robust treatment response compared toValchlor® during 12-week treatment coursePRINCETON, N.J., April 2, 2026 /PRNewswire/
About this update from Soligenix, Inc.
[{"type":"text","content":"HyBryte™ demonstrates more rapid and robust treatment response compared toValchlor® during 12-week treatment coursePRINCETON, N.J., April 2, 2026 /PRNewswire/ -- Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today that the positive results of its comparability study evaluating HyBryte™ (synthetic hypericin) versus Valchlor® (mechlorethamine) for the treatment of cutaneous T-cell lymphoma (CTCL) have been published in Oncology and Therapy. \n \n \n \n \n \n \n \n\"Being able to share the important results of this clinical trial with the world through publication in Oncology and Therapy is a privilege and highlights the clinical significance of our work with HyBryte™,\" stated Brian Poligone, MD, PhD, Director of the Rochester Skin Lymphoma Medical Group, Fairport, NY, and Principal Investigator for the comparability study. \"Despite the small study sample size and a randomization that lead to the HyBryte™ group having patients with more extensive disease, HyBryte™ performed well and the results are consistent with previous studies demonstrating its rapid onset of action and benign safety profile compared to one of the most widely prescribed approved drugs for early-stage CTCL. The positive effect this therapy can have for patients and the outstanding safety profile that HyBryte™ continues to demonstrate are very encouraging.\"The purpose of the study was to obtain preliminary comparative assessment of the safety and efficacy of HyBryte™ versus Valchlor® following 12 weeks of treatment as measured in 3 to 5 prospectively identified index lesions for each patient. At the end of the 12-week treatment period, 60% of the HyBryte™ patients met the prospectively defined level of \"Treatment Success\" (≥50% improvement in their cumulative mCAILS score compared to Baseline) compared to only 20% of the Valchlor® patients; although due to the small sample size the results do not achieve statistical significance. Of the remaining two HyBryte™ patients that did not achieve treatment success, both saw a substantial (≥30%) reduction in their mCAILS score. In contrast, in the Valchlor® group, of the remaining 4 patients that did not achieve treatment success, one worsened an...