Business
Solid Biosciences Doses First Participant in First-in-Class Phase 1b FALCON Trial Evaluating SGT-212 Dual-Route Gene Therapy for the Treatment of Friedreich’s Ataxia
Initial data from the Phase 1b FALCON trial expected in H2 2026, subject to participant enrollmentCHARLESTOWN, Mass., Jan. 12, 2026 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced that the first participant has been dosed in FALCON, the Company’s Phase 1b, first-in-human clinical trial evaluating SGT-212, its investigational gene therapy for
About this update from Solid Biosciences Inc.
[{"type":"image","alt":"Solid Biosciences Inc.","displaySize":"","headline":null,"caption":"Solid Biosciences Inc.","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":169,"url":"https://media.zenfs.com/en/globenewswire.com/5e97e2fffdb55638e3c89b04065944ef"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/sCFNOglu1.GlZmhoavpsMQ--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTIzNztjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/5e97e2fffdb55638e3c89b04065944ef","width":300,"height":169}},"lazy":false},{"type":"text","content":"Initial data from the Phase 1b FALCON trial expected in H2 2026, subject to participant enrollment","length":98,"tagName":"p"},{"type":"text","content":"CHARLESTOWN, Mass., Jan. 12, 2026 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the “Company” or “Solid”), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced that the first participant has been dosed in FALCON, the Company’s Phase 1b, first-in-human clinical trial evaluating SGT-212, its investigational gene therapy for the treatment of Friedreich’s ataxia (FA).","length":445,"tagName":"p"},{"type":"text","content":"SGT-212 is a first-in-class investigational gene therapy for the treatment of FA that employs a dual-route administration designed to target the neurologic, cardiac and systemic manifestations of the disease, which are key drivers of morbidity and mortality seen in FA. SGT-212 is delivered through a precise, stereotactic, MRI-guided intradentate nuclei (IDN) infusion to the cerebellar dentate nuclei followed by an intravenous (IV) infusion, with the goal of restoring therapeutic levels of frataxin.","length":503,"tagName":"p"},{"type":"text","content":"Gabriel Brooks, M.D., Chief Medical Officer of Solid Biosciences, commented: “Dosing our first participant in this first-in-human Friedreich’s ataxia trial is a momentous achievement for the FA community and for Solid Biosciences. We believe our novel, real-time, MRI-guided stereotactic delivery approach is one that truly embodies the promise of precision genetic medicine. We are ecstatic to report that intra-procedural MRI-imaging confirmed intradentate nuclei targeting and coverage that surpassed our expectations as well as thresholds we believe are necessary for a potential treatment effect. While these are ear...