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Sol-Gel Hosts Investor Call to Discuss Positive Results from Twyneo® Phase 3 Program in Acne Vulgaris
Conference call with Sol-Gel management and U.S. key opinion leader today at 8:00 a.m. Eastern time NESS ZIONA, Israel, Jan. 08, 2020 (GLOBE NEWSWIRE) --
About this update from Sol-gel Technologies Ltd.
[{"type":"text","content":"Conference call with Sol-Gel management and U.S. key opinion leader today at 8:00 a.m. Eastern time NESS ZIONA, Israel, Jan. 08, 2020 (GLOBE NEWSWIRE) -- Sol-Gel Technologies, Ltd. (NASDAQ: SLGL) will host a conference call today to discuss results from two Phase 3 clinical trials for Twyneo®, an investigational combination of microencapsulated tretinoin 0.1% and microencapsulated benzoyl peroxide 3% cream being studied in patients with acne vulgaris. In the SGT-65-04 and SGT-65-05 clinical trials, Twyneo demonstrated statistically significant improvements in all co-primary endpoints, as compared to vehicle, and was found to be well-tolerated.\n Sol-Gel management and U.S. key opinion leader Hilary Baldwin, M.D., will discuss results from the Phase 3 Twyneo clinical trial program via conference call and webcast today at 8:00 a.m. Eastern Time. Dr. Baldwin is past President of the American Acne and Rosacea Society, a Clinical Associate Professor of Dermatology at Rutgers Robert Wood Johnson School of Medicine, and Director of the Acne Treatment and Research Center. The conference call can be accessed by dialing 877-282-0504 for participants in the U.S. or Canada and 270-215-9895 for international callers (conference ID: 5779723). The webcast and slide presentation can be accessed live via the Events & Presentations section of the Company’s website at http://ir.sol-gel.com. SGT-65-04 and SGT-65-05 Trials Design To assess the efficacy and safety of Twyneo, 858 subjects, aged nine and older, with moderate-to-severe acne were enrolled in two multicenter, randomized, double-blind, parallel-group, vehicle-controlled trials (SGT-65-04 and SGT-65-05) at 63 sites across the U.S. Subjects were randomized at a 2:1 ratio to be treated once-daily with either Twyneo (n=571) or vehicle cream (n=287) for 12 weeks. The co-primary endpoints for both trials included: the proportion of patients who succeeded in achieving at least a two grade reduction from baseline and Clear (grade 0) or Almost Clear (grade 1) at Week 12 on a 5-point Investigator Global Assessment (IGA) scale; an absolute change from baseline in inflammatory lesion count at Week 12; and an absolute change from baseline in non-inflammatory lesion count at Week 12. About TwyneoTwyneo is an investigational, antibiotic-free, fixed-dose combination of microencapsulated tretinoin 0.1% and...