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SkinBiotix shows efficacy in first human study
SkinBiotix shows efficacy in first human study.
About this update from Skinbiotherapeutics Plc
[{"type":"text","content":"\n \nRNS Number : 3464V SkinBioTherapeutics PLC 08 April 2019 \n\nSkinBioTherapeutics plc\n \nSkinBiotix® shows efficacy in first human study\n \nManchester, UK - 8 April 2019 - SkinBioTherapeutics plc (AIM: SBTX - \"SkinBioTherapeutics\" or the \"Company\"), a life science company focused on skin health, provides the results of its first human study.\nThe study was primarily undertaken to show the effects of SkinBiotix® on the barrier of healthy skin. An important secondary endpoint was to show that the technology is safe and well tolerated in a large group of people (129) using it twice a day for an extended period of time (29 days). \n \nThe results of this independent study demonstrate that SkinBiotix® is safe, well tolerated and has efficacy in certain age groups and time points.\n \nThe study design involved three groups:\n \n· Group 1 applied the active (cream containing SkinBiotix®) to one leg and nothing to the other\n· Group 2 applied the vehicle (cream containing no SkinBiotix®) to one leg and nothing to the other\n· Group 3 applied the vehicle to one leg and active to the other.\n \nMeasures of the barrier were then performed in all groups at 15 days and 29 days. The primary measures were Corneometry - a measure of how hydrated the skin is, and Transepidermal water loss (\"TEWL\") -a measure of water loss from the skin. A change to the barrier might be expected to be reflected in an increase in skin hydration or a reduction in TEWL. Some additional measurements of skin elasticity were also taken.\n \nOur data showed:\n \n1) None of the 129 volunteers experienced any adverse skin reactions to the active.\n2) A statistically significant increase in skin hydration at day 15 with the active, which was better than that produced by the vehicle. This effect was seen in the group under 50 years old. At day 29 there was no difference in skin hydration between any of the groups.\n3) A small but statistically significant decrease in TEWL with the active at day 29 in the group over 60 years old.\n4) In other age groups and also in measures of skin elasticity there was no difference between the vehicle and the active.\n \nThe results of t...