Press release
SINOVAC Announces Positive Data on Booster Shots of CoronaVac®, Induces Strong Immune Response in Adult and Elderly Populations
CoronaVac® generates good immune memory after second dose Third dose of vaccine significantly increased neutralizing antibody levels in adults and elderly
About this update from Sinovac Biotech, Ltd.
[{"type":"text","content":"\nCoronaVac® generates good immune memory after second dose\n\nThird dose of vaccine significantly increased neutralizing antibody levels in adults and elderly population \n\nFindings indicate a third dose of CoronaVac® is well-tolerated in the elderly population \n\nNo serious vaccine-related adverse reactions reported\n\n BEIJING--(BUSINESS WIRE)--\nSINOVAC Biotech Ltd. (NASDAQ: SVA) (“Sinovac” or the “Company”), a leading provider of biopharmaceutical products in China, announced today the publication of two papers, which are available on Medrxiv. The publications detail findings from clinical studies on the immunogenicity, safety, and immune response of CoronaVac® in two- and three-dose schedules. The results indicate that a third booster dose of CoronaVac® induces a strong immune response in healthy adults with no serious adverse reactions related to the vaccine. This research provides important scientific data and supplement existing research to help policymakers develop strategies for vaccine rollout and timing of booster doses.\n\nThe first paper, titled Immunogenicity and safety of a third dose, and immune persistence of CoronaVac vaccine in healthy adults aged 18-59 years: interim results from a double-blind, randomized, placebo-controlled phase 2 clinical trial, includes published data on the immunogenicity and safety profile of a two-dose schedule, as well as interim results on immune persistence and the immunogenicity and safety of a third dose of CoronaVac® in healthy adults aged 18 to 59 years old.\n\nThe study is part of the placebo-controlled, double-blind phase II clinical trial in healthy adults aged 18 to 59 years old, conducted in China. Participants were randomly assigned (1:1:1:1) to one of four schedules to receive a third dose of vaccine, 28 or 6 months after two two-dose regiments, 14 or 28 days apart. The immunization schedule of the three-dose regimens for the four arms were: (1) days 0, 14, 42; (2) days 0, 14, 54; (3) days 0, 28, 56; and (4) days 0, 28, 268.\n\nThe results indicated that a two-dose schedule generates good immune memory. A third dose given 6 to 8 months after the second dose quickly induced a strong immune response, and the neutralizing antibody titers at day 28 after the third dose increased by three to five times higher than the levels recorded on day 28 after the second injection. ...