Business
Shattuck Labs Reports First Quarter 2022 Financial Results and Recent Business Highlights
– Dose escalation ongoing in Phase 1 clinical trial of SL-172154 in platinum-resistant ovarian cancer; combination trial with liposomal doxorubicin on track
About this update from Shattuck Labs, Inc.
[{"type":"text","content":"– Dose escalation ongoing in Phase 1 clinical trial of SL-172154 in platinum-resistant ovarian cancer; combination trial with liposomal doxorubicin on track to begin in 2H’2022; full dose-escalation data in monotherapy and initial data in combination both expected in 1H’2023 – – Dose escalation ongoing for Phase 1 clinical trial of SL-172154 in acute myeloid leukemia and higher-risk myelodysplastic syndromes with initial monotherapy and combination dose escalation data expected in 1H’2023 – – Enrollment ongoing for Phase 1 dose-escalation trial of SL-279252 with top-line data expected in 2H’2022 – AUSTIN, TX and DURHAM, NC, May 12, 2022 (GLOBE NEWSWIRE) -- Shattuck Labs, Inc. (Shattuck) (NASDAQ: STTK), a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, today reported financial results for the quarter ended March 31, 2022 and provided recent business highlights. “We are now completing the monotherapy dose-escalation study for SL-172154 in ovarian cancer patients and are focused on the initiation and rapid clinical execution of multiple combination studies in both hematologic and solid tumors. This expansion is a critical step in establishing SL-172154 as both a first- and best-in-class CD47 inhibitor and CD40 agonist, and we continue to expect SL-172154 to differentiate from other CD47 inhibitors and CD40 agonists in terms of safety, pharmacodynamic activity, and efficacy in combinations. The next 18 months are shaping up to be a defining period for establishing CD47 inhibition as a key macrophage checkpoint in multiple indications, and we look forward to providing initial combination data from SL-172154 in the first half of 2023,” said Taylor Schreiber, M.D., Ph.D., and Chief Executive Officer of Shattuck. First Quarter 2022 Recent Business Highlights and Other Recent Developments ARC Clinical-Stage Pipeline and Preclinical Pipeline SL-172154 (SIRPα-Fc-CD40L) Continued Enrollment of SL-172154 Phase 1A Dose-Escalation Clinical Trial in Platinum-Resistant Ovarian Cancer: This open-label, multi-center, dose-escalation clinical trial is evaluating the safety, tolerability, pharmacokinetics, anti-tumor activity, and pharmacodynamic effects of SL-172154 administered intravenously in pati...