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Senti Bio Highlights Preclinical Data from Logic-Gated Gene Circuit CAR-NK Cell Therapy SENTI-202 at ASH Annual Meeting and Investor Event
– ASH poster presentation summarizes preclinical data from SENTI-202, an off-the-shelf CAR-NK cell therapy candidate engineered with a logic-gated gene
About this update from Senti Biosciences Holdings, Inc.
[{"type":"text","content":"– ASH poster presentation summarizes preclinical data from SENTI-202, an off-the-shelf CAR-NK cell therapy candidate engineered with a logic-gated gene circuit and multi-armed with crIL-15, that is advancing toward clinical development for hematologic malignancies – – SENTI-202 is on track for IND filing in 2H 2023 – – SENTI-202 aims to more precisely target tumor cells in CD33 and/or FLT3 expressing tumors such as acute myeloid leukemia and myelodysplastic syndrome, while sparing healthy cells – – Senti Bio Investor Event to include an AML expert; in-person and webcast at 12:30 p.m. ET/11:30 a.m. CT today – NEW ORLEANS, Dec. 11, 2022 (GLOBE NEWSWIRE) -- Senti Biosciences, Inc. (Nasdaq: SNTI) (“Senti Bio”), a biotechnology company innovating next-generation cell and gene therapies using its proprietary gene circuit platform, today announced a presentation at the American Society of Hematology (ASH) Annual Meeting in New Orleans. The presentation highlights preclinical data that led to the selection of SENTI-202 as the Company's lead oncology candidate. Senti Bio plans to evaluate SENTI-202 in patients with CD33 and/or FLT3 expressing hematologic malignancies including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), with an anticipated filing of an Investigational New Drug (IND) application in the second half of 2023. “The preclinical data presented at ASH demonstrates the progress made with our lead logic-gated gene circuit CAR-NK cell therapy, SENTI-202, which incorporates our OR gate, NOT gate, and calibrated release IL-15 technologies,\" said Tim Lu, MD, PhD, Chief Executive Officer and Co-Founder of Senti Bio. \"In both in vitro and in vivo models, we observed that SENTI-202 had significant and precise cancer-killing activity against AML, and significant protection of healthy cells from off-tumor cytotoxicity. We are hopeful that these preclinical results will translate into the clinic for patients with AML and MDS. The success of these gene circuits in the clinic would broadly enable off-the-shelf CAR-NK cells that precisely kill cancer cells while sparing healthy cells across multiple tumor indications.\" In addition to Senti Bio presenting these data and the initial SENTI-202 clinical development plan, today’s Investor Event will also feature a presentation by Stephen A. Strickland, Jr., MD, MSCI, Directo...