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SCYNEXIS Announces Publication of Review Article Highlighting Ibrexafungerp as a Potential Novel Treatment for Invasive Mold Infections in the Journal of Fungi
Ibrexafungerp demonstrates activity against deadly fungal pathogens included in the World Health Organization’s (WHO) first fungal pathogens priority list
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[{"type":"text","content":"Ibrexafungerp demonstrates activity against deadly fungal pathogens included in the World Health Organization’s (WHO) first fungal pathogens priority list\nJERSEY CITY, N.J., Nov. 07, 2022 (GLOBE NEWSWIRE) -- SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology company pioneering innovative medicines to overcome and prevent difficult-to-treat and drug-resistant fungal infections, today announced the publication of a review article highlighting the potential use of ibrexafungerp as a novel treatment option for invasive infections caused by opportunistic molds in the Journal of Fungi. “This review in the Journal of Fungi showcases ibrexafungerp as a potential treatment for invasive mold infections, which are a growing threat to public health, particularly in immunocompromised patients,” said David Angulo, M.D., Chief Medical Officer of SCYNEXIS and lead author of the publication. “The importance of this topic is further underscored by the recently published WHO fungal priority pathogens list to guide research, development and public health action, validating the need for new antifungal agents such as ibrexafungerp, which has shown a spectrum of activity against most of the fungal pathogens in this priority list.” In the article, authors describe the need for novel treatment strategies to improve outcomes of difficult-to-treat invasive mold infections, as currently available treatments are limited, resistance against current antifungals is common and mortality remains high. Ibrexafungerp’s mechanism of action and mode of administration offer advantages compared to other antifungals, including activity against drug-resistant species and convenient once-daily oral dosing. Preclinical studies featured in the article illustrate ibrexafungerp’s activity against a broad variety of fungal pathogens, including prevalent Aspergillus species, Mucorales as well as other molds often involved in systemic diseases. The authors emphasize that preclinical studies justify further clinical development of ibrexafungerp not only as a potential monotherapy for mold infections, but also as combination therapy or as a potential prophylaxis agent in patients with high risk of severe disease. Two ongoing clinical trials will provide further insight into the potential of ibrexafungerp for the treatment of invasive mold infections. The FURI open-label study of ibr...