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Scilex Holding Company Amends its License Agreement with Romeg Therapeutics, LLC, For the Worldwide Rights to Commercialize Gloperba®, an FDA-Approved Prophylactic Treatment for Painful Gout Flares in Adults
Gloperba® is the first and only liquid oral version of the anti-gout medicine colchicine indicated for the prophylaxis of painful gout flares in adults.Over
About this update from Scilex Holding Company
[{"type":"text","content":"Gloperba® is the first and only liquid oral version of the anti-gout medicine colchicine indicated for the prophylaxis of painful gout flares in adults.Over 70% of gout patients have comorbid conditions that may require dose adjustments, and such patients could be a potential target population for Gloperba®1Over 17% of gout patients on colchicine experienced severe gastrointestinal side effects like diarrhea. These patients may benefit from flexible dosing offered by Gloperba®2Unlike other colchicine formulations, GLOPERBA® liquid oral solution allows for precision dosing and reduction of daily dose in patients with severe renal impairment (0.3 mg/day).The worldwide incidence of gout flares is estimated to be around 0.1 to 0.3% of the population, with a significantly higher prevalence in males compared to females, and a rising trend due to factors like increasing obesity rates and aging populations; however, exact figures can vary depending on the study and region analyzed.3The global population of individuals with gout increased in the past 30 years from 22 million (95% UI 17.52-27.37) to 53 million (95% UI 43.38-66.34).4 PALO ALTO, Calif., Jan. 16, 2025 (GLOBE NEWSWIRE) -- Scilex Holding Company (Nasdaq: SCLX, “Scilex” or “Company”), an innovative revenue-generating company focused on acquiring, developing and commercializing non-opioid pain management products for the treatment of acute and chronic pain and, following the formation of its proposed joint venture with IPMC Company, in neurodegenerative and cardiometabolic disease, today announced that it has entered into an amendment (the “Amendment”) to its existing license agreement with Romeg Therapeutics, LLC (“Romeg”), entered into in June 2022, for ex-US rights to Gloperba®. Romeg had previously granted Scilex an exclusive license to commercialize Gloperba® only in the U.S. Gloperba® is taken orally like cough syrup. The dosage of 0.6mg per 5ml (teaspoon) can fill that important void in treatment where patients may have difficulty swallowing pills. It can also provide more adjustable dosing, titration and dose-reduction options in specific populations, especially for gout patients with renal or hepatic impairment and reduce side effects with the goal to improve patient convenience and disease management. According to Nature Reviews Rheumatology, gout is a common chronic c...