Business
Investor Update
Investor Update.
About this update from Scancell Holdings Plc
[{"type":"text","content":"\n \nRNS Number : 3310P Scancell Holdings Plc 01 October 2013 \n \n\n1 October 2013\n \nScancell Holdings Plc\n('Scancell')\n \nInvestor update showcases Moditope® platform and updates SCIB1 trial progress\n \nScancell Holdings Plc, (AIM:SCLP), the developer of novel immunotherapies for the treatment of cancer, will today hold an investor update. Following an introduction by Prof. Peter Stern, Institute of Cancer Sciences, University of Manchester, Dr Richard Goodfellow and Prof Lindy Durrant, Scancell's joint CEOs will present a business update as well an overview of the ImmunoBody® platform and SCIB1 clinical programme, including its current status. A detailed introduction to the new Moditope® platform will also be given for the first time. \n \nProf Durrant will review the SCIB1 clinical trial programme and confirm that the ongoing studies remain on track. Further results from this trial are expected by the end of 2013. SCIB1 is Scancell's first cancer immunotherapy and is a product of the Company's ImmunoBody® platform. It is being developed for the treatment of malignant melanoma and is currently in Phase 1/2 clinical trials. Encouraging results from Part 1 of the study have previously been presented and provide the first clinical evidence that Scancell's ImmunoBody® immunotherapy approach is producing an immune response in cancer patients which may also be associated with clinical benefit. Prof Durrant will today add that four out of the six evaluable patients treated with either the 2mg or 4mg dose of SCIB1 still remain alive. The mean survival time in this group of five Stage IV and one Stage IIIb patients is currently 21 months from trial entry. \n \nIn view of the positive results and minimal side effects seen with the 4mg dose (Part 1) of the SCIB1 Phase 1/2 trial, the Company has initiated evaluation of an 8mg dose in up to six patients with measurable tumours. Five patients have been recruited to date: one patient will no longer be evaluable due to delivery of an incomplete dose of SCIB1 and a further patient was not able to complete dosing within the required timeframe. A safety review of the data from the 8 mg cohort in Part 1 will be conducted and, if adequate safety is demonstrated, Scancell plans to recruit a further 10 p...