Business
Collaboration to manufacture COVID-19 vaccine
Collaboration to manufacture COVID-19 vaccine.
About this update from Scancell Holdings Plc
[{"type":"text","content":"\n \n \n \n RNS Number : 8853A\n Scancell Holdings Plc\n 02 October 2020\n \n \n \n \n 2 October 2020\n \n \n \n \n \n Cobra Biologics selected to manufacture plasmids for Phase I clinical trial of Scancell's COVID-19 vaccine in 2021\n \n \n \n \n \n The collaboration will ensure GMP production of material for the Phase 1 clinical trial of Scancell's DNA vaccine against SARS-CoV-2\n \n \n \n \n \n \n Oxford and Keele, UK, 2\n \n \n October 2020. Cobra Biologics (Cobra), part of the Cognate BioServices family, an international CDMO manufacturer of biological materials and pharmaceuticals, and Scancell Holdings plc (Scancell), the developer of novel immunotherapies for the treatment of cancer and infectious disease, today announced that they have entered into a collaboration for Cobra to manufacture Scancell's COVID-19 vaccine. The agreement covers Good Manufacturing Pracatice (GMP) production of plasmid DNA needed to generate the DNA vaccine, against SARS-CoV-2, for use in a Phase 1 clinical trial in 2021 (COVIDITY). The project is funded by an Innovate UK grant awarded to the consortium between Scancell, the University of Nottingham and Trent University, as previously announced in August 2020. \n \n \n \n \n \n Scancell's DNA vaccine will target the SARS-CoV-2 nucleocapsid (N) protein plus the key receptor binding domain of the spike (S) protein to generate both T cell responses and virus neutralising antibodies against the SARS-CoV-2 virus. This new vaccine has the potential to provide long lasting immunity against COVID-19 by generating protection not only against this strain, but also against new strains of coronavirus that may arise in the future.\n \n \n \n \n \n The GMP production of plasmid DNA represents a crucial development in the production of a COVID-19 vaccine for use in the Phase 1 clinical trial, COVIDITY. Increasing production of plasmids to large scale and according to GMP requires management of the scale-up process to ensure plasmids are of therapeutic-grade quality. Cobra's long-established plasmid production platform along with in-house expertise will ensure the highest quality plasmids are produced for COVIDITY. The initial stages of GMP manufacture are scheduled to start imminently. \n \n \n \n \n \n \n Dr Cliff Holloway, Chief Executive Officer, Scancell, commented...