Press release
Savara Presented Data at the European Respiratory Society (ERS) International Congress 2022
AUSTIN, Texas--(BUSINESS WIRE)-- Savara Inc. (Nasdaq: SVRA), a clinical stage biopharmaceutical company focused on rare respiratory diseases, presented three
About this update from Savara, Inc.
[{"type":"text","content":" AUSTIN, Texas--(BUSINESS WIRE)--\nSavara Inc. (Nasdaq: SVRA), a clinical stage biopharmaceutical company focused on rare respiratory diseases, presented three posters at the ERS International Congress 2022 that took place September 4-6th in Barcelona, Spain.\n\nBelow are summaries of each poster presented:\n\nAbstract #2170: “IMPALA: Efficacy Measures in Patients with Autoimmune Pulmonary Alveolar Proteinosis (aPAP) Who Required Whole Lung Lavage” presented by Y. Inoue, M.D., Ph.D.\n\n\nPresented data from a post hoc analysis of the IMPALA clinical trial evaluating the benefit of continuous daily administration of inhaled molgramostim 300 μg vs placebo among patients with aPAP who required whole lung lavage (WLL) during the double-blind treatment period. A total of 10 patients underwent WLL in the treatment period (molgramostim: n=4, placebo: n=6)\n\n\nData demonstrated that patients treated with molgramostim after undergoing WLL had greater improvements in endpoint measures of gas exchange, including alveolar-arterial oxygen difference (A-aDO2) and diffusing capacity of the lungs for carbon monoxide (DLco) corrected for hemoglobin levels. Additionally, patients reported improved health status, as measured by St. George’s Respiratory Questionnaire-Total and -Activity, when compared with placebo-treated patients .\n\n\nClick here to view the poster\n\n\nAbstract #1154: “Safety and Tolerability of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)” presented by F. Bonella, M.D., Ph.D.\n\n\nIncluded safety data from an open-label, non-controlled extension study of IMPALA (IMPALA-X) in which 60 patients received treatment with inhaled molgramostim 300 μg/day administered intermittently (1 week on and 1 week off). This study was discontinued early as results from IMPALA did not support this dosing regimen.\n\n\nIn IMPALA-X, no new safety signals were observed and the most common treatment-related adverse events after 93.4 patient-years of exposure were mild-to-moderate cough, nasopharyngitis, and respiratory tract infection.\n\n\nClick here to view the poster\n\n\nAbstract #3136: “IMPALA-2: Choice of DLco as a Primary Endpoint in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)” presented by B. Trapnell, M.D.\n\n\nDescribed rationale for using DLco as a primary endpoint in the IMPALA-2 clinical trial, including...