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Sana Biotechnology Highlights Preclinical Data from Hypoimmune and Fusogen Platforms at the International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting
Hypoimmune (HIP)-modified CD19-directed CAR T cells have the potential to serve as a universal off-the-shelf therapy that provides long-term durability of
About this update from Sana Biotechnology, Inc.
[{"type":"text","content":"Hypoimmune (HIP)-modified CD19-directed CAR T cells have the potential to serve as a universal off-the-shelf therapy that provides long-term durability of response without immunosuppression HIP-modified primary pancreatic islet cells alleviate diabetes in humanized mice and avoid immune rejection without immunosuppression Intramuscular administration of islet cells in humanized mice does not impact cell function and viability and may serve as a preferred administration route for patients Demonstration of in vivo delivery of genetic payloads to human hematopoietic stem/progenitor cells SEATTLE, June 16, 2023 (GLOBE NEWSWIRE) -- Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on changing the possible for patients through engineered cells, today announced preclinical data from six presentations, including two oral presentations, at the International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting. “Our leading presence at ISSCR showcased key preclinical data generated from our programs using our hypoimmune and fusogen platforms,” said Doug Williams, Ph.D., Sana’s President of Research and Development. “The ability to transplant allogeneic cells engineered to evade immune detection without immunosuppression with durable cell persistence and functionality has the potential to transform the field of cell therapy, as well as medicine as a whole. At this conference, much of our data focused on the hypoimmune platform’s ability to avoid immune detection in various preclinical models as well as the potential of incorporating this platform into pancreatic islet cells for the treatment of type 1 diabetes. We also shared data demonstrating in vivo delivery of various genetic payloads to human hematopoietic stem/progenitor cells, highlighting an important capability with the fusogen platform. Later this year, we look forward to sharing initial clinical data from our hypoimmune platform which should help us understand the translatability of these and other preclinical data to humans, including data for our allogeneic CD19-directed CAR T cells for the treatment of B-cell cancers and data for primary human pancreatic islet cells for the treatment of type 1 diabetes.” Oral PresentationsOn Thursday, June 15, an oral presentation titled “Human Hypoimmune Primary Pancreatic Islets Evade Allogeneic and Autoimmune Rejection Witho...