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Sana Biotechnology Announces Preclinical Data Published in Nature Biotechnology Demonstrating its Hypoimmune-Engineered Cells Escape Immune Detection and Survive While Remaining Fully Functional
Hypoimmune-modified allogeneic iPSCs evade immune response and rejection without immunosuppression in non-human primate model Long-term survival and immune
About this update from Sana Biotechnology, Inc.
[{"type":"text","content":"Hypoimmune-modified allogeneic iPSCs evade immune response and rejection without immunosuppression in non-human primate model Long-term survival and immune evasion of hypoimmune-modified allogeneic iPSCs at least equivalent to survival of autologous iPSCs CD47 overexpression provided robust protection of hypoimmune-modified allogeneic cells from killing by the innate immune system versus other engineering approaches SEATTLE, May 08, 2023 (GLOBE NEWSWIRE) -- Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on changing the possible for patients through engineered cells, today announced that Nature Biotechnology has published a paper titled “Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.” The preclinical studies published in this paper used Sana’s hypoimmune (HIP) technology to engineer HIP-modified allogeneic cells to escape immune detection in the absence of immune suppression. In vivo studies in fully immunocompetent non-human primates (NHPs) demonstrated that HIP-modified allogeneic cells survived without immunosuppression for the length of the studies (16 weeks and >40 weeks). An additional humanized mouse study showed that HIP-modified induced pluripotent stem cells (iPSCs) that are differentiated into pancreatic islet cells were immune evasive and ameliorated diabetes in vivo. “We have demonstrated in numerous preclinical studies that our hypoimmune-engineered cells persist and function without eliciting an immune response,” said Doug Williams, PhD, Sana’s President of Research and Development. “These published data in rigorous translational models that closely imitate the human immune system support our previous findings, most importantly that HIP-modified allogeneic cells avoid immune recognition and rejection without immune suppression. We are incorporating the HIP technology into multiple therapeutic candidates in our pipeline and look forward to reporting our first human clinical data later this year.” Allogeneic HIP Cells Avoid Immune Activation and Escape Systemic Immune Rejection in NHPsNHP iPSCs were engineered using HIP technology to generate HIP-modified iPSCs. A cross-over study was performed where NHP HIP iPSCs (HIPallo) were administered to NHPs previously sensitized to non-engineered NHP iPSCs (wtallo) and wtallo cells were administer...