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Sagimet Biosciences Presents Preclinical Results Supporting the Therapeutic Potential of its FASN inhibitor in Combination with Semaglutide and a Comprehensive Lipidomic Analysis of Interim FASCINATE-2 Data at AASLD - The Liver Meeting® 2023
Combination treatment of a FASN inhibitor with semaglutide, a GLP-1 receptor agonist, improved several biomarkers associated with NASH in a mouse model and
About this update from Sagimet Biosciences Inc. - Series A
[{"type":"text","content":"Combination treatment of a FASN inhibitor with semaglutide, a GLP-1 receptor agonist, improved several biomarkers associated with NASH in a mouse model and showed a significant improvement in liver fibrosis, while semaglutide alone did not significantly improve fibrosis Reductions of circulating lipids associated with cardiovascular risk were observed in denifanstat-treated patients in the FASCINATE-2 Phase 2b clinical trial interim analysis, with numerical separation from placebo at Week 4 and statistically significant responses at Week 13 FASCINATE-2 Phase 2b clinical trial of denifanstat in F2-F3 NASH patients is fully enrolled; on track to report week 52 topline results, including liver biopsy, in the first quarter of 2024 SAN MATEO, Calif., Nov. 10, 2023 (GLOBE NEWSWIRE) -- Sagimet Biosciences Inc. (Sagimet, Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel fatty acid synthase (FASN) inhibitors that target dysfunctional metabolic pathways, today announced the presentation of preclinical results detailing artificial intelligence (AI) based digital pathology of Sagimet’s FASN inhibitor alone or in combination with semaglutide in a preclinical mouse model of nonalcoholic steatohepatitis (NASH). A comprehensive lipidomic analysis from the interim analysis of the FASCINATE-2 Phase 2b clinical trial will also be presented in a late-breaking poster session at the American Association for the Study of Liver Diseases (AASLD) - The Liver Meeting® 2023 held November 10-14, 2023 in Boston. “The preclinical combination results underscore the importance of developing disease modifying therapies, such as denifanstat, for NASH patients,” said Marie O’Farrell, Ph.D., Sagimet’s Senior Vice President of Research and Development. “There is a sizeable population of NASH patients with type 2 diabetes. Our data, consistent with published clinical results, suggests that GLP-1 therapy alone is associated with major body weight loss but does not significantly reduce liver fibrosis, a predictor of outcome in NASH. We are pleased that the combination treatment significantly decreased liver fibrosis as well as NAFLD activity score (NAS) in this preclinical model, and believe it could warrant further clinical evaluation. At this time, we are focused on continuing to advance denifanstat as a potential monotherapy and are on track...