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Antibody Program Results & Orphan Drug Indication
Antibody Program Results & Orphan Drug Indication.
About this update from Coiled Therapeutics Plc
[{"type":"text","content":"\n\n19 June 2023\n \nRoquefort Therapeutics plc\n(\"Roquefort Therapeutics\" or the \"Company\")\n \nAntibody Program Results & Orphan Drug Indication\n \nRoquefort Therapeutics (LSE:ROQ), the Main Market listed biotech company focused on developing first-in-class medicines in the high value and high growth oncology market, is pleased to announce the progress of its anti-cancer antibody programs targeting Midkine expressing cancers.\nFollowing the announcement in January 2023 where the Company announced the Midkine antibody programs, targeting metastatic breast cancer and metastatic lung cancer, successfully demonstrated in vivo safety, Roquefort Therapeutics has continued the development of its antibody portfolio with the Company's research partners at La Trobe University. The Company is now releasing the first in vivo efficacy results for its anti-Midkine antibodies CAB-101 (ROQA2) and CAB-102 (ROQA1), including a new program for an osteosarcoma orphan drug indication.\nCAB-101 and CAB-102 are the lead programs in the Company's family of patented humanised antibodies, which were developed in-house, to target Midkine-expressing solid cancers. The in vivo efficacy study tested the anti-cancer killing ability of CAB-101 and CAB-102 in a validated experimental model of osteosarcoma. Treatment with CAB-101 was found to produce a statistically significant reduction in lung metastasis, and CAB-102 was found to reduce proliferation (growth rate) of the primary tumour. The more detailed experimental results remain under embargo pending publication at a leading cancer research conference.\nCAB101 and CAB102 treat solid cancers, the market for which was estimated to be $32 billion in 2021 and growing with a 7.8% CAGR[1]. Osteosarcoma is the Company's first orphan drug indication and reflects the strategic decision to target cancer niches in which, there remains a high unmet clinical need (24% to 64% 5-year survival rate)[2], an accelerated development pathway[3] and the potential to offer a best-in-class treatment in a significant market niche.\nMedicines to treat an orphan drug indication may be awarded market exclusivity for 7 years in the USA and 10 years in the EU and UK[4], tax credits for the clinical drug testing cost, fee reductions and, on average, will have a significantly higher success...