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Dermavant Showcases New Long-Term Durability and Tolerability Data from Phase 3 PSOARING 3 Trial of Tapinarof Cream for Adults with Plaque Psoriasis at the 2022 AAD Annual Meeting
Tapinarof demonstrated continued improvements for up to 52 weeks in efficacy outcomes, quality of life measures, and tolerability scores with no associated
About this update from Roivant Sciences Ltd.
[{"type":"text","content":"Tapinarof demonstrated continued improvements for up to 52 weeks in efficacy outcomes, quality of life measures, and tolerability scores with no associated tachyphylaxisTapinarof was well-tolerated in sensitive skin and intertriginous areas with majority of patients experiencing no irritation for up to 52 weeksTapinarof was well tolerated with long term use and demonstrated continued and durable improvement in quality of life LONG BEACH, Calif., and BASEL, Switzerland, March 25, 2022 (GLOBE NEWSWIRE) -- Dermavant Sciences, a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, today announced Phase 3 PSOARING 3 long-term extension study results demonstrating durable improvements across efficacy outcomes, quality of life measures, and tolerability scores with investigational tapinarof cream 1% once daily (QD) for the treatment of plaque psoriasis in adults. The data, from prespecified endpoints of the Phase 3 PSOARING 3 long-term extension study, are being presented at the 2022 American Academy of Dermatology (AAD) Annual Meeting, held March 25-29 in Boston. “Plaque psoriasis is often a lifelong condition that can have a significant negative impact on many aspects of a patient’s life. Due to limitations in current psoriasis therapies, there is a strong need for new topical treatments for adults suffering with this condition,” said April W. Armstrong, M.D., M.P.H., a dermatologist with Keck Medicine of USC and Professor of Dermatology and Associate Dean for Clinical Research in Dermatology at the Keck School of Medicine of USC. “The durable improvements demonstrated by tapinarof in PSOARING 3 across efficacy outcomes, quality of life and tolerability scores are encouraging. As a clinician, I am excited about the possibility of a potential new therapy in tapinarof for patients suffering from plaque psoriasis.” Eligible patients who completed either PSOARING 1 or 2, which were 12-week pivotal studies of tapinarof in adults with plaque psoriasis, could enroll in PSOARING 3. PSOARING 3 consisted of an additional 40 weeks of open-label intermittent treatment with tapinarof based on Physician Global Assessment (PGA) score, followed by a 4-week follow-up. Patients who were randomized to tapinarof in PSOARING 1 or 2 and who also completed PSOARING 3 received ta...