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Rhythm Pharmaceuticals Announces Two Publications Detailing Burden of Hyperphagia and Obesity on Patients and Caregivers Living with Bardet-Biedl Syndrome
Results of The CAREgiver Burden in BBS (CARE-BBS) study show multifaceted burden of hyperphagia BOSTON, July 19, 2023 (GLOBE NEWSWIRE) -- Rhythm
About this update from Rhythm Pharmaceuticals, Inc.
[{"type":"text","content":"Results of The CAREgiver Burden in BBS (CARE-BBS) study show multifaceted burden of hyperphagia\nBOSTON, July 19, 2023 (GLOBE NEWSWIRE) -- Rhythm Pharmaceuticals, Inc. (Nasdaq: RYTM), a commercial-stage biopharmaceutical company focused on transforming the lives of patients and their families living with hyperphagia and severe obesity caused by rare melanocortin-4 receptor (MC4R) pathway diseases, today announced two new publications detailing the burden of hyperphagia and obesity for adult caregivers, families and patients living with Bardet-Biedl Syndrome (BBS) based on results of The CAREgiver Burden in BBS (CARE-BBS) study. The research is published in the peer-reviewed journal, The Orphanet Journal of Rare Diseases. “BBS is characterized by hyperphagia – an insatiable hunger that results in extreme food seeking behaviors – and early-onset, severe obesity, both of which have broad negative impacts on the lives of patients living with BBS and their caregivers,” said Prof. Andrea M. Haqq, M.D., Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta. “These results demonstrate that hyperphagia and severe obesity associated with BBS negatively affect performance in school, work and social relationships. Importantly, the findings from the CARE-BBS study were similar across countries, demonstrating the universality of hyperphagia and underscoring the need for therapies that can effectively treat hyperphagia in order to alleviate the extensive clinical and nonclinical impacts of the disease.” “Burden of Hyperphagia and Obesity in Bardet-Biedl Syndrome: a Multi-country Survey,” includes results from a cross-sectional survey of 242 adult caregivers of patients with BBS across the United States, the United Kingdom, Canada and Germany. Caregivers of patients with BBS reported that hyperphagia has broad impacts, well beyond contributing to obesity. Caregivers observed hyperphagic behaviors throughout the day, most frequently negotiating for food (90%) and waking up and asking or looking for food during the night (88%). Hyperphagia had at least a moderate negative impact on most patients’ mood/emotions (56%), sleep (54%), school (57%), leisure (62%), and familial relationships (51%). “Caregiver Burden in Bardet-Biedl Syndrome: Findings from the CARE-BBS Study,” quantifies caregiver burden associated with obesity...