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Reviva Pharmaceuticals Announces Presentation of Clinical Pharmacology Studies Data on Brilaroxazine at the ASPET 2023 Annual Meeting
Data reinforce brilaroxazine’s differentiated clinical pharmacology and safety profile Brilaroxazine may be co-administered with other drugs metabolized by
About this update from Reviva Pharmaceuticals Holdings, Inc.
[{"type":"text","content":"Data reinforce brilaroxazine’s differentiated clinical pharmacology and safety profile Brilaroxazine may be co-administered with other drugs metabolized by CYP3A inhibitors Metabolism and excretion profiles of brilaroxazine were similar across mice, canines, and humans CUPERTINO, Calif., May 22, 2023 (GLOBE NEWSWIRE) -- Reviva Pharmaceuticals Holdings, Inc. (NASDAQ: RVPH) (“Reviva” or the “Company”), a clinical-stage pharmaceutical company developing therapies that seek to address unmet medical needs in the areas of central nervous system (CNS), respiratory and metabolic diseases, has presented two posters on promising clinical pharmacology and safety studies data on the novel serotonin-dopamine stabilizer brilaroxazine at the American Society for Pharmacology and Experimental Therapeutics (ASPET) 2023 annual meeting took place in St. Louis, Missouri, USA, May 18-21, 2023. The ASPET posters are available at revivapharma.com/publications. Brilaroxazine is currently in phase 3 clinical trials for schizophrenia and topline data from the pivotal phase 3 is anticipated in mid this year. “We were pleased to present data in humans and animals further characterizing the differentiated pharmacological and safety profile, and predictable pharmacokinetics (PK), metabolism and excretion profiles of brilaroxazine at this year’s ASPET meeting,” said Laxminarayan Bhat, Ph.D., Founder, President, and CEO of Reviva. “These data support the concomitant use of brilaroxazine with other medications metabolized by CYP3A4 as most schizophrenia patients take multiple concomitant medications. Importantly, brilaroxazine has demonstrated similar metabolism, and excretion profiles in humans and preclinical species canines and mice which further support brilaroxazine’s differentiated safety profile.” Key poster highlights support brilaroxazine’s differentiated clinical pharmacology and safety profile: CYP3A inhibition and induction exert limited effects on brilaroxazine pharmacokineticsCYP3A4 metabolizes several standard of care antipsychotics (e.g., aripiprazole, lurasidone, risperidone, quetiapine, cariprazine, brexpiprazole, lumetaperone, and clozapine) which often leads to significant plasma drug concentration changes when co-administered with another drug metabolized by CYP3A4 inhibitors or inducers due to drug-drug interactions and changes efficacy an...