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Resverlogix Presents Important New Data at the Annual American Society of Nephrology Kidney Week Conference
Resverlogix Presents Important New Data at the Annual American Society of Nephrology Kidne...
About this update from Resverlogix Corp.
[{"type":"text","content":"\n\n\n\nResverlogix Presents Important New Data at the Annual American Society of Nephrology Kidney Week Conference\n\n/* Style Definitions */\nspan.prnews_span\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\na.prnews_a\n{\ncolor:blue;\n}\nli.prnews_li\n{\nfont-size:8pt;\nfont-family:\"Arial\";\ncolor:black;\n}\np.prnews_p\n{\nfont-size:0.62em;\nfont-family:\"Arial\";\ncolor:black;\nmargin:0in;\n}\n.prntac{\nTEXT-ALIGN: CENTER\n}\n\n\n\n\n\n\nResverlogix Presents Important New Data at the Annual American Society of Nephrology Kidney Week Conference\nCanada NewsWire\nCALGARY, Nov. 9, 2015\n\n\n\nApabetalone and Alkaline Phosphatase Data Highlighted in Multiple Presentations\n\nTSX Exchange Symbol: RVX\n\n\n\nCALGARY, Nov. 9,  2015 /CNW/ - Resverlogix Corp. (TSX:RVX, the Company) today announced the presentation of important new data detailing the actions of apabetalone (RVX-208) in cardiovascular disease (CVD) and chronic kidney disease (CKD) patients at the American Society of Nephrology (ASN) Kidney Week  conference in San Diego, CA, USA. The data was summarized in two poster presentations. The first was entitled 'Apabetalone, a First-in-Class Epigenetic BET-Inhibitor, has Effects on Alkaline Phosphatase (ALP) and Estimated Glomerular Filtration Rate (eGFR) in Subjects with CVD and CKD; a Post-hoc Analysis of the ASSERT, SUSTAIN and ASSURE Clinical Trials'. The data contained in this presentation showed that in patients with a baseline eGFR<60 mL/min/1.73 m2, treatment with RVX-208 for 12-26 weeks lead to an improvement in eGFR and a significant reduction in ALP (p<0.01). In the second presentation entitled 'Alkaline Phosphatase Lowering by Selective BET inhibition, a Novel Mechanism for Major Adverse Cardiac Events (MACE) Reduction in High Risk CVD, Diabetes and CKD Patients, a Post-hoc Analysis of Phase 2b Studies with Apabetalone'. This presentation contained data gathered in the SUSTAIN and ASSURE trials showing that baseline ALP levels were significantly higher in all patients who suffered from MACE versus those who were free from MACE. One of the most significant findings was in apabetalone treated patients (n=331). In this treated population, patients who suffered from MACE had an increase of ALP by 3 IU/L vs. baseline, while in the event free patients (n=313) ALP decreased by 8 IU/L.  T...